Document Detail

Comparison of cell proliferation in the centre and advancing fronts of oral squamous cell carcinomas using Ki-67 index.
MedLine Citation:
PMID:  14521519     Owner:  NLM     Status:  MEDLINE    
The cell proliferation status of 60 oral squamous cell carcinomas from Sri Lankan subjects was examined by immunohistochemistry using the Ki-67 index. A comparison was made between the indices derived from the centre of the tumours and those derived from the invasive fronts of the same tumours. There was a positive correlation between the two indices suggesting a clonal expansion of malignant cells, but the mean index derived for the invasive fronts (29.75 11.64) was significantly higher than the mean index for the body of these tumours (25.65 11.64). Thus, at a given time, more peripheral cells at the invasive front are proliferating and this compartment is likely to be more informative in prognostic and other behavioural studies involving the cell cycle. In squamous carcinomas, increased and uncontrolled cell proliferation at the invasive front may be one feature contributory to the invasion.
U Dissanayake; N W Johnson; K A A S Warnakulasuriya
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cell proliferation     Volume:  36     ISSN:  0960-7722     ISO Abbreviation:  Cell Prolif.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-02     Completed Date:  2003-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9105195     Medline TA:  Cell Prolif     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-64     Citation Subset:  IM    
Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
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MeSH Terms
Carcinoma, Squamous Cell / pathology*
Cell Division
Ki-67 Antigen / analysis*
Mitotic Index
Mouth Neoplasms / pathology*
Tumor Markers, Biological / analysis
Reg. No./Substance:
0/Ki-67 Antigen; 0/Tumor Markers, Biological

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