| Comparison of cefodizime with various cephalosporins for their indirect effect on the human neutrophil oxidative burst in vitro. | |
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MedLine Citation:
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PMID: 2127416 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cefodizime, a 2-amino-thiazolyl cephalosporin, is reported to display in-vitro, ex-vivo and in-vivo immunomodulatory properties; in particular, it enhances the survival of mice infected with cefodizime-resistant pathogens. We have used an in-vitro model to assess the indirect effect of this drug (compared with other cephalosporins) on the neutrophil (PMN) oxidative response. Pseudomonas aeruginosa was employed as the bacterial target for cefodizime and cefotaxime (MICs greater than 128 mg/l), cefsulodin (MIC 16 mg/l) and ceftazidime (MIC 32 mg/l). After overnight growth in the presence of subinhibitory concentrations of each drug (10 mg/l), the altered filamentous P. aeruginosa induced a stronger oxidative response of PMN than untreated control bacteria. For all cephalosporins this was related to alterations of bacterial structure leading to increased deposits of antibodies and/or complement. Furthermore, increased non-opsonin dependent stimulation of the PMN oxidative burst was obtained; the strongest response was observed with cefodizime-treated P. aeruginosa in the case of low responder PMN, which displayed a deficient response after stimulation by control bacteria. The possibility that cefodizime could enhance this PMN function in opsonin-deficient patients requires further investigation. |
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Authors:
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M T Labro; J el Benna |
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Publication Detail:
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Type: Comparative Study; In Vitro; Journal Article |
Journal Detail:
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Title: The Journal of antimicrobial chemotherapy Volume: 26 Suppl C ISSN: 0305-7453 ISO Abbreviation: J. Antimicrob. Chemother. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-04-15 Completed Date: 1991-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513617 Medline TA: J Antimicrob Chemother Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 49-57 Citation Subset: IM |
Affiliation:
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INSERM U.294, CHU Xavier Bichat, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cefotaxime
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analogs & derivatives*,
pharmacology Cephalosporins / pharmacology* Humans Microbial Sensitivity Tests Neutrophils / drug effects, metabolism* Oxidation-Reduction Pseudomonas aeruginosa / drug effects, immunology, ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/Cephalosporins; 63527-52-6/Cefotaxime; 69739-16-8/cefodizime |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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