Document Detail


Comparison of cefazolin, cefamandole, vancomycin, and LY146032 for prophylaxis of experimental Staphylococcus epidermidis endocarditis.
MedLine Citation:
PMID:  2831815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We evaluated antibiotic prophylaxis in the rabbit model of experimental endocarditis with three strains of Staphylococcus epidermidis of differing susceptibility patterns. For the first strain, which was highly susceptible to methicillin and cephalosporins, vegetations grew S. epidermidis for all 15 untreated rabbits compared with 1 of 20 rabbits receiving cefazolin, 3 of 20 receiving cefamandole, none of 20 receiving vancomycin, and none of 20 receiving LY146032. For the second strain, which was methicillin resistant but cephalosporin susceptible, vegetations were positive for 14 of 15 untreated controls, 4 of 20 receiving cefazolin, 5 of 22 receiving cefamandole, none of 20 receiving vancomycin, and none of 20 receiving LY146032. For the third strain, which was methicillin resistant and only intermediately susceptible to cephalosporin antibiotics, vegetation cultures were positive for 15 of 17 untreated controls, 14 of 21 receiving cefazolin, 11 of 20 receiving cefamandole, 5 of 20 receiving vancomycin, and 0 of 22 receiving LY146032. In conclusion, these studies in the endocarditis model indicate that cefazolin and cefamandole have some protective value against certain strains of S. epidermidis. Vancomycin and LY146032, however, were more active than cephalosporins for all three strains included in this analysis. These findings support the need for trials of vancomycin and LY146032 prophylaxis in patients undergoing placement of prosthetic heart valves.
Authors:
L J Wheat; J W Smith; J Reynolds; A T Bemis; T Treger; J A Norton
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  32     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM    
Affiliation:
Department of Medicine, Indiana University Medical Center, Indianapolis 46226.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Bacterial Agents / therapeutic use*
Cefamandole / therapeutic use
Cefazolin / therapeutic use
Cephalosporins / pharmacology
Daptomycin
Drug Resistance, Microbial
Endocarditis, Bacterial / prevention & control*
Methicillin / pharmacology
Penicillin Resistance
Peptides / therapeutic use
Rabbits
Staphylococcal Infections / prevention & control*
Staphylococcus epidermidis / drug effects
Vancomycin / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 0/Peptides; 103060-53-3/Daptomycin; 1404-90-6/Vancomycin; 25953-19-9/Cefazolin; 34444-01-4/Cefamandole; 61-32-5/Methicillin
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