Document Detail


Comparison of cause distribution between elderly and non-elderly patients with chronic cough.
MedLine Citation:
PMID:  18596372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The causes of chronic cough in elderly patients have not been specifically investigated. Therefore, it remains to be determined whether chronic cough differs between elderly and non-elderly patients.
OBJECTIVES: To investigate the distribution of causes of chronic cough in elderly patients in comparison with etiologies of chronic cough observed in non-elderly patients.
METHODS: From 2,989 new patients presenting consecutively to the Department of Respiratory Medicine of the Tongji Hospital over a 1.5-year period, 287 patients with chronic cough were enrolled in the study. Patients aged > or =60 years were assigned to the elderly group. The elderly group comprised 104 patients and the non-elderly group the remaining 183 patients. The causes of cough were primarily evaluated according to a modification of Irwin's anatomic diagnostic protocol which included induced sputum cytology, verified by the specific therapy.
RESULTS: Cough-variant asthma (34.6 vs. 41.5%) and upper airway cough syndrome (19.3 vs. 23.5%) were the most common causes of chronic cough both in the elderly and non-elderly groups. The distribution of causes and frequency were significantly different between elderly and non-elderly groups: angiotensin-converting enzyme inhibitor (ACEI)-induced cough (16.3 vs. 1.7%, chi(2) value = 22.12, p < 0.001) and gastroesophageal reflux disease (GERD; 10.6 vs. 3.7%, chi(2) value = 5.14, p = 0.02) were more common in the elderly group.
CONCLUSIONS: A more frequent incidence of ACEI-induced cough and GERD is the distinctive feature in the cause distribution between elderly and non-elderly patients with chronic cough.
Authors:
Weili Wei; Li Yu; Hanjing Lu; Lan Wang; Cuiqin Shi; Wei Ma; Yang Huang; Zhongmin Qiu
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-07-03
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  77     ISSN:  1423-0356     ISO Abbreviation:  Respiration     Publication Date:  2009  
Date Detail:
Created Date:  2009-04-06     Completed Date:  2009-07-17     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  259-64     Citation Subset:  IM    
Copyright Information:
Copyright 2008 S. Karger AG, Basel.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Cough / etiology*
Female
Humans
Male
Middle Aged
Prospective Studies

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