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Comparison of caudal analgesia between ropivacaine and ropivacaine with clonidine in children: A randomized controlled trial.
MedLine Citation:
PMID:  23162389     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Addition of clonidine to ropivacaine (0.2%) can potentially enhance analgesia without producing prolonged motor blockade. The aim of the present study was to compare the post-operative pain relieving quality of ropivacaine 0.2% and clonidine mixture to that of plain ropivacaine 0.2% following caudal administration in children.
METHODS: In a prospective, double-blinded, randomized controlled trial, 30 ASA 1 pediatric patients undergoing infraumbilical surgery were randomly allocated to receive a caudal injection of either plain ropivacaine 0.2% (1 ml/kg) (group A) or a mixture of ropivacaine 0.2% (1 ml/kg) with clonidine 2 μg/kg (group B). Objective pain score and need for supplemental analgesics were compared during the 1(st) 24 hours postoperatively. Residual post-operative sedation and motor blockade were also assessed.
RESULTS: Significantly prolonged duration of post-operative analgesia was observed in group B (P<0.0001). Heart rate and blood pressure were not different in 2 groups. Neither motor blockade nor post-operative sedation varied significantly between the groups.
CONCLUSION: The combination of clonidine (2 μg/kg) and ropivacaine 0.2% was associated with an improved quality of post-operative analgesia compared to plain 0.2% ropivacaine. The improved analgesic quality of the clonidine-ropivacaine mixture was achieved without causing any significant degree of post-operative sedation or prolongation of motor blockade.
Authors:
Arpita Laha; Sarmila Ghosh; Haripada Das
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi journal of anaesthesia     Volume:  6     ISSN:  0975-3125     ISO Abbreviation:  Saudi J Anaesth     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2012-11-20     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101500601     Medline TA:  Saudi J Anaesth     Country:  India    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  -    
Affiliation:
Department of Anaesthesiology, R. G. Kar Medical College, Kolkata, West Bengal, India.
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