Document Detail

Comparison of casual, ambulatory and self-measured blood pressure in a study of nitrendipine vs bisoprolol.
MedLine Citation:
PMID:  1352496     Owner:  NLM     Status:  MEDLINE    
In a double-blind, placebo-controlled study the antihypertensive efficacy and tolerability of a single morning dose of either 10 mg bisoprolol (n = 26) or 20 mg nitrendipine (n = 27) were investigated. Blood pressure was measured by three techniques: (1) Casual blood pressure 24 h after the dose; (2) ambulatory 24-h whole-day monitoring; and (3) self-recorded blood pressure in the morning 24 h after the dose (6-8 a.m.) and in the evening (6-8 p.m.). After 4 weeks of therapy bisoprolol had produced a highly significant reduction in blood pressure as assessed by causal, ambulatory day- and night-time monitoring, and self-measured morning and evening readings. Bisoprolol was significantly more effective than nitrendipine, which did not induce a significant reduction in the ambulatory night-time recordings. Whole-day ambulatory blood pressure profiles showed an antihypertensive effect of bisoprolol throughout the entire 24-h period. 24-h blood pressure curves after nitrendipine demonstrated a markedly shorter duration of action, with no reduction in early morning blood pressure. Adverse effects and tolerability of the two drugs were comparable. The average changes in systolic and diastolic blood pressure after bisoprolol and nitrendipine in 2-h periods of ambulatory monitoring (6-8 a.m. and 6-8 p.m.) and self-measured blood pressure (6-8 a.m. and 6-8 p.m.) showed a good agreement between ambulatory and self-measured blood pressure determinations with no significant difference between the methods. The results show that 24 h antihypertensive efficacy was more pronounced for bisoprolol than for nitrendipine at the doses studied.(ABSTRACT TRUNCATED AT 250 WORDS)
T Mengden; B Bättig; M Schubert; T Jeck; B Weisser; C Buddeberg; W Vetter
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  42     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1992  
Date Detail:
Created Date:  1992-08-10     Completed Date:  1992-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  569-75     Citation Subset:  IM    
Department of Internal Medicine, University Hospital, Zurich, Switzerland.
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MeSH Terms
Adrenergic beta-Antagonists / adverse effects,  therapeutic use*
Blood Pressure Determination / methods*
Double-Blind Method
Heart Rate / drug effects
Hypertension / drug therapy*
Middle Aged
Nitrendipine / adverse effects,  therapeutic use*
Propanolamines / adverse effects,  therapeutic use*
Self Care
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Propanolamines; 39562-70-4/Nitrendipine; 66722-44-9/Bisoprolol

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