Document Detail

Comparison of case-cohort estimators based on data on premature death of adult adoptees.
MedLine Citation:
PMID:  14673939     Owner:  NLM     Status:  MEDLINE    
A case-cohort sample of adoptees was collected to investigate genetic and environmental influences on premature death, which motivated us to supplement existing simulation results to explore the performance of various estimators proposed for case-cohort samples of survival data. We studied six regression coefficients estimators, which differ with regard to the weighting scheme used in a pseudo-likelihood function, and two different estimators of their variances. Compared to earlier simulation studies, we changed the following conditions: type of explanatory variable, the distribution of lifetimes, and the percentage of deaths in the full cohort. The latter condition affected the performance of the estimated variances of the regression coefficients, where we found a systematic bias of the estimator, proposed by Self and Prentice, dependent on the percentages of deaths. This dependence of percentages of death was different for different sizes of case-cohort studies. A robust variance estimator showed a better overall performance. The estimators of regression coefficients compared did not differ much, the estimators proposed by Kalbfleisch and Lawless and by Prentice performing very well. Results of the case-cohort data of adoptees were not in conflict with earlier findings of a moderate genetic influence on premature death in adulthood.
Liselotte Petersen; Thorkild I A Sørensen; Per Kragh Andersen
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Statistics in medicine     Volume:  22     ISSN:  0277-6715     ISO Abbreviation:  Stat Med     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-12-15     Completed Date:  2004-03-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  3795-803     Citation Subset:  IM    
Copyright Information:
Copyright 2003 John Wiley & Sons, Ltd.
Danish Epidemiology Science Centre at the Institute of Preventive Medicine, Copenhagen University Hospital, DK-1399 Copenhagen K, Denmark.
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MeSH Terms
Cohort Studies
Proportional Hazards Models
Survival Analysis*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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