Document Detail

Comparison of cardiovascular changes after administration of gadodiamide injection and gadopentetate dimeglumine in dogs.
MedLine Citation:
PMID:  9084778     Owner:  NLM     Status:  MEDLINE    
RATIONALE AND OBJECTIVES: The authors compared the cardiovascular effects of gadodiamide injection and gadopentetate dimeglumine. METHODS: Gadodiamide injection or gadopentetate dimeglumine, each at doses of 0.3 or 1.5 mmol per kilogram of body weight, or saline volume control was administered intravenously in the cephalic vein of anesthetized dogs. Hemodynamic parameters, electrocardiographic parameters, and peripheral flow were measured. RESULTS: Neither the low or high dose of gadodiamide injection caused statistically significant (P < .05) changes in any of the measured cardiovascular parameters. High doses of gadopentetate dimeglumine, however, significantly decreased left ventricular and systemic blood pressure and significantly depressed left ventricular contractility (P < .05). CONCLUSION: Gadodiamide injection caused no observable cardiovascular effects, whereas high doses of gadopentetate dimeglumine caused cardio-depressive and hypotensive effects.
J Bøkenes; S O Hustvedt; H Refsum
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Academic radiology     Volume:  4     ISSN:  1076-6332     ISO Abbreviation:  Acad Radiol     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-06-03     Completed Date:  1997-06-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9440159     Medline TA:  Acad Radiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  204-9     Citation Subset:  IM    
Department of Pharmacology, Research and Development, Nycomed Imaging AS, Oslo, Norway.
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MeSH Terms
Contrast Media / administration & dosage,  toxicity*
Drug Combinations
Gadolinium / administration & dosage,  toxicity*
Gadolinium DTPA
Hemodynamics / drug effects*
Injections, Intravenous
Meglumine / administration & dosage,  toxicity*
Organometallic Compounds / administration & dosage,  toxicity*
Pentetic Acid / administration & dosage,  analogs & derivatives*,  toxicity
Reg. No./Substance:
0/Contrast Media; 0/Drug Combinations; 0/Organometallic Compounds; 122795-43-1/gadodiamide; 6284-40-8/Meglumine; 67-43-6/Pentetic Acid; 7440-54-2/Gadolinium; 80529-93-7/Gadolinium DTPA

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