| Comparison of cardiac structural and functional changes in obese otherwise healthy adults with versus without obstructive sleep apnea. | |
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MedLine Citation:
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PMID: 17478161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Obstructive sleep apnea (OSA) and obesity have been linked to systolic and diastolic dysfunction of the left ventricle. Right ventricular function is poorly understood in the 2 clinical conditions. Data from this study show that otherwise healthy obese patients with OSA had increased an left atrial volume index compared with similarly obese patients without OSA (16.3 +/- 1.2 ml/m in obese patients without OSA vs 20.2 +/- 1.0 ml/m in those with OSA, p = 0.02) and altered diastolic function reflected by changes in mitral annular late diastolic velocity (-5.7 +/- 0.7 cm/s in obese patients without OSA vs -7.3 +/- 0.7 cm/s in those with OSA, p = 0.007), mitral annular early diastolic velocity (-7.9 +/- 0.6 cm/s in obese patients without OSA vs -6.4 +/- 0.3 cm/s in those with OSA, p = 0.05), and early to late diastolic annular ratio >1 (82% of obese patients without OSA vs 26% of those with OSA, p = 0.001), which may be signs of early subclinical impairment of cardiac function. Importantly, healthy obese subjects had similarly increased left ventricular mass compared with obese patients with OSA but normal diastolic function and left atrial size. There was a trend toward abnormal right ventricular filling in patients with OSA, measured by altered superior vena cava diastolic velocity during expiration (-15 +/- 2 cm/s in obese patients without OSA vs -10 +/- 3 cm/s in those with OSA, p = 0.2) and a tendency toward diastolic dysfunction reflected by decreased lateral tricuspid annular early diastolic velocity (-7.2 +/- 0.5 cm/s in obese patients without OSA vs -6.1 +/- 0.5 cm/s in those with OSA, p = 0.1) beyond that seen in obesity alone. In conclusion, OSA independent of obesity may induce cardiac changes that could predispose to atrial fibrillation and heart failure. |
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Authors:
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Maria E Otto; Marek Belohlavek; Abel Romero-Corral; Apoor S Gami; Gregory Gilman; Anna Svatikova; Raouf S Amin; Francisco Lopez-Jimenez; Bijoy K Khandheria; Virend K Somers |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2007-03-20 |
Journal Detail:
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Title: The American journal of cardiology Volume: 99 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-05-04 Completed Date: 2007-06-05 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1298-302 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Flow Velocity / physiology Case-Control Studies Echocardiography Heart Ventricles / physiopathology*, ultrasonography* Humans Male Middle Aged Myocardial Contraction / physiology Obesity / complications, physiopathology*, ultrasonography* Polysomnography Sleep Apnea, Obstructive / complications, physiopathology*, ultrasonography* Stroke Volume / physiology Vena Cava, Superior / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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HL-61560/HL/NHLBI NIH HHS; HL-65176/HL/NHLBI NIH HHS; HL-68555/HL/NHLBI NIH HHS; HL-70602/HL/NHLBI NIH HHS; HL-73211-01/HL/NHLBI NIH HHS; M01-RR00585/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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