| Comparison of cardiac and pulmonary-specific quality-of-life measures in pulmonary arterial hypertension. | |
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MedLine Citation:
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PMID: 21273391 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Studies systematically comparing the performance of health-related quality-of-life (HRQoL) instruments in pulmonary arterial hypertension (PAH) are lacking. We sought to address this by comparing cardiac and respiratory-specific measures of HRQoL in PAH. We prospectively assessed HRQoL in 128 patients with catheterisation-confirmed PAH at baseline and at 6, 12 and post-24 month follow-up visits. Cardiac-specific HRQoL was assessed using the Minnesota Living with Heart Failure Questionnaire (LHFQ); respiratory-specific HRQoL was assessed using the Airways Questionnaire 20 (AQ20); and general health status was assessed using the 36-item Short Form physical component summary (SF-36 PCS). The LHFQ and AQ20 were highly intercorrelated. Both demonstrated strong internal consistency and converged with the SF-36 PCS. Both discriminated patients based on World Health Organization (WHO) functional class, 6-min walking distance (6MWD) and Borg dyspnoea index (BDI), with the exception of a potential floor effect associated with low 6MWD. The LHFQ was more responsive than the AQ20 to changes over time in WHO functional class, 6MWD and BDI. In multivariate analyses, the LHFQ and AQ20 were each longitudinal predictors of general health status, independent of functional class, 6MWD and BDI. In conclusion, both cardiac-specific and respiratory-specific measures appropriately assess HRQoL in most patients with PAH. Overall, the LHFQ demonstrates stronger performance characteristics than the AQ20. |
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Authors:
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H Chen; T De Marco; E A Kobashigawa; P P Katz; V W Chang; P D Blanc |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2011-01-27 |
Journal Detail:
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Title: The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology Volume: 38 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-02 Completed Date: 2012-01-24 Revised Date: 2012-09-28 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 608-16 Citation Subset: IM |
Affiliation:
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Dept of Medicine, University of California, San Francisco, CA 94143-0924, USA. hubert.chen@ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cohort Studies Female Follow-Up Studies Health Status Hemodynamics Humans Hypertension Hypertension, Pulmonary / diagnosis*, physiopathology* Male Middle Aged Multivariate Analysis Prospective Studies Quality of Life Questionnaires Respiration |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL086585/HL/NHLBI NIH HHS; K23 HL086585-01A1/HL/NHLBI NIH HHS; K23 HL086585-02/HL/NHLBI NIH HHS; K23 HL086585-03/HL/NHLBI NIH HHS; K23 HL086585-04/HL/NHLBI NIH HHS; K23 HL086585-05/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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Eur Respir J. 2011 Sep;38(3):512-3
[PMID:
21885415
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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