Document Detail


Comparison of captopril and ibopamine in mild to moderate heart failure.
MedLine Citation:
PMID:  9391292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine the effects of ibopamine 100 mg three times daily compared with captopril 25 mg three times daily on exercise capacity in patients with chronic heart failure. DESIGN: A randomised, double blind, parallel group comparison of the addition of ibopamine versus captopril during a period of 24 weeks. SETTING: 26 outpatient cardiology clinics in seven European countries. PATIENTS: 266 patients, with mild to moderate chronic heart failure (New York Heart Association (NYHA) functional class II, 81% and III, 19%) and evidence of an enlarged left ventricle. Patients received concomitant treatment with diuretics and/or digitalis. MAIN OUTCOME MEASURE: Exercise duration after 24 weeks of treatment, compared with baseline. RESULTS: Mean (SD) ejection fraction was 29 (8)% and the baseline exercise duration in the captopril and ibopamine groups 665 (160) and 675 (174) seconds, respectively. At the end of the study, exercise duration had improved in both groups, by 29 seconds in the ibopamine group (P < 0.01), and by 24 seconds in the captopril group (P < 0.05). There was no difference between groups (P = 0.69, 95% confidence interval -22 to 33). NYHA class, signs and symptoms score, and dyspnoea and fatigue index improved equally in both groups. The total number of adverse events was the same in both treatment groups, but gastrointestinal complaints occurred more often in the ibopamine group. The number of patients with premature withdrawals was no different. CONCLUSIONS: No difference was detected between the effect of captopril and ibopamine on exercise time in patients with mild to moderate heart failure during a treatment period of 24 weeks.
Authors:
H J Dohmen; P H Dunselman; P A Poole-Wilson
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  78     ISSN:  1355-6037     ISO Abbreviation:  Heart     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-12-17     Completed Date:  1997-12-17     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  285-90     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, Bosch Medicentrum, 's-Hertogenbosch, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Angiotensin-Converting Enzyme Inhibitors / administration & dosage*,  therapeutic use
Captopril / administration & dosage*,  therapeutic use
Deoxyepinephrine / administration & dosage,  analogs & derivatives*,  therapeutic use
Dopamine Agonists / administration & dosage*,  therapeutic use
Double-Blind Method
Drug Administration Schedule
Exercise Test
Female
Heart Failure / drug therapy*,  physiopathology
Humans
Male
Middle Aged
Prospective Studies
Chemical
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Dopamine Agonists; 501-15-5/Deoxyepinephrine; 62571-86-2/Captopril; 66195-31-1/ibopamine
Comments/Corrections

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