| Comparison of cancer cell surfaces of the lower reproductive tract by scanning electron microscopy. | |
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MedLine Citation:
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PMID: 930973 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The squamous cells of the cervix simulate those of the vagina and vulva both histologically and by scanning electron microscopy. However, in areas of the cervix undergoing active metaplasia, there are cells which share some of the characteristics demonstrated by scanning electron microscopy of both squamous and columnar epithelium. In these cells there is a wide range of characteristics of each cell type, suggesting a possible gradual transition from columnar to squamous epithelium. Furthermore, the cells of severe dysplasia and of intraepithelial and invasive squamous cancers of the cervix, though histologically similar to those of vaginal and vulvar cancers, are distinctly different when examined by scanning electron microscopy. These findings suggest that both metaplastic and neoplastic squamous cells are derived from the same progenitor columnar cells of the cervix, by orderly transition in the former and by atypical transformation in the latter. Second, the distinctiveness from the vaginal and vulvar cells indicates different embryonic stem cell lines. |
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Authors:
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A I Sherman |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 129 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 893-908 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Carcinoma in Situ
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embryology,
pathology Carcinoma, Squamous Cell / embryology, pathology Female Genital Neoplasms, Female / pathology* Metaplasia Microscopy, Electron, Scanning Uterine Cervical Dysplasia / pathology Uterine Cervical Neoplasms / embryology, pathology Vaginal Neoplasms / embryology, pathology Vulvar Neoplasms / embryology, pathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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