| Comparison of calculated and direct low density lipoprotein cholesterol determinations in a routine laboratory. | |
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MedLine Citation:
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PMID: 15293974 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Low density lipoprotein cholesterol (LDL-C) concentrations form the basis for treatment guidelines established for hyperlipidaemic patients. LDL-C concentrations are commonly calculated using the Friedwald formula (FF) which has several limitations. Recently, direct methods for LDL-C estimation have been developed which are suitable for routine laboratories. OBJECTIVE: To compare serum LDL-C concentrations determined by a direct assay and the Friedwald formula. DESIGN: Cross-sectional study. SETTING: Mater Hospital Laboratory, Nairobi, Kenya. METHODS: The clinical performance of the two methods was evaluated by analysing 211 fresh plasma samples from fasting adult patients. The samples were divided into four groups-normolipidaemic; and Types IIa, IIb and IV hyperlipidaemias. RESULTS: The Friedwald formula (FF) correlated best with the direct assay in the normolipidaemic samples (r = 0.879; y= 0.468 + 0.852x). Direct LDL-C values were significantly lower than the FF in the Type IIa hyperlipidaemia samples (paired differences 0.38 +/- 0.62). There was only 65% agreement between the two methods in the borderline high LDL-C group of the National Cholesterol Education Program (NCEP) classification (LDL-C 3.36-4.14 mmol/L). CONCLUSION: There is lack of agreement between the FF and the Abbott direct LDL-C assay. If the two methods are used interchangeably, there may be confusion in the classification and control of lipid lowering medication for patients with hyperlipidaemia. |
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Authors:
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A A Amayo; S Kirera |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: East African medical journal Volume: 81 ISSN: 0012-835X ISO Abbreviation: East Afr Med J Publication Date: 2004 Mar |
Date Detail:
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Created Date: 2004-08-05 Completed Date: 2004-09-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372766 Medline TA: East Afr Med J Country: Kenya |
Other Details:
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Languages: eng Pagination: 154-8 Citation Subset: IM |
Affiliation:
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Departmnent of Clinical Chemistry, College of Health Sciences, University of Nairobi, P.O Box 19676, Nairobi, Kenya. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Chemical Analysis / methods* Cholesterol, LDL / blood* Cross-Sectional Studies Female Humans Hyperlipidemias / blood, classification Lipoproteins / blood Male Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Lipoproteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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