Document Detail


Comparison of cabergoline and bromocriptine in patients with asymptomatic incidental hyperprolactinemia undergoing ICSI-ET.
MedLine Citation:
PMID:  20459348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We retrospectively assessed outcomes of in vitro fertilisation in groups of women with asymptomatic incidentally discovered hyperprolactinaemia (AIH) undergoing ovarian stimulation and ICSI-ET relative to the types of dopamine agonist and gonadotropin releasing hormone analogue used. Of 5840 women who underwent COH and ICSI-ET, 239 were included in the study; 122 had been treated with cabergoline, and 117 with bromocriptine, during the COH. The mean age, duration of stimulation, and total number of gonadotropin ampules employed were comparable in the two groups using the agonist and antagonist protocols, as were the number of oocytes retrieved and the proportion of mature MII and fertilised (2pn) oocytes. There were no significant differences in implantation, pregnancy, and miscarriage rates between the agonist and antagonist arms of the study. The cost of treatment was significantly higher with cabergoline than with bromocriptine (p = 0.0001). However, side effect rate was significantly higher with bromocriptine than with cabergoline (15.3% vs. 2.5%; p = 0.0004). In conclusion, we found that cabergoline and bromocriptine showed no differences in IVF outcomes and pregnancy results in patients with AIH.
Authors:
Mustafa Bahceci; Alper Sismanoglu; Ulun Ulug
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  26     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-14     Completed Date:  2010-09-13     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  505-8     Citation Subset:  IM    
Affiliation:
Department of Infertility and Reproductive Medicine, Istanbul German Hospital, Istanbul, Turkey. mustafabahceci@bahceci.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Bromocriptine / therapeutic use*
Databases, Factual
Dopamine Agonists / therapeutic use
Ergolines / therapeutic use*
Female
Humans
Hyperprolactinemia / complications,  drug therapy*
Infertility, Female / complications,  therapy*
Pregnancy
Pregnancy Rate
Retrospective Studies
Sperm Injections, Intracytoplasmic*
Treatment Outcome
Chemical
Reg. No./Substance:
0/Dopamine Agonists; 0/Ergolines; 25614-03-3/Bromocriptine; LL60K9J05T/cabergoline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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