| Comparison of cabergoline and bromocriptine in patients with asymptomatic incidental hyperprolactinemia undergoing ICSI-ET. | |
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MedLine Citation:
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PMID: 20459348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We retrospectively assessed outcomes of in vitro fertilisation in groups of women with asymptomatic incidentally discovered hyperprolactinaemia (AIH) undergoing ovarian stimulation and ICSI-ET relative to the types of dopamine agonist and gonadotropin releasing hormone analogue used. Of 5840 women who underwent COH and ICSI-ET, 239 were included in the study; 122 had been treated with cabergoline, and 117 with bromocriptine, during the COH. The mean age, duration of stimulation, and total number of gonadotropin ampules employed were comparable in the two groups using the agonist and antagonist protocols, as were the number of oocytes retrieved and the proportion of mature MII and fertilised (2pn) oocytes. There were no significant differences in implantation, pregnancy, and miscarriage rates between the agonist and antagonist arms of the study. The cost of treatment was significantly higher with cabergoline than with bromocriptine (p = 0.0001). However, side effect rate was significantly higher with bromocriptine than with cabergoline (15.3% vs. 2.5%; p = 0.0004). In conclusion, we found that cabergoline and bromocriptine showed no differences in IVF outcomes and pregnancy results in patients with AIH. |
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Authors:
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Mustafa Bahceci; Alper Sismanoglu; Ulun Ulug |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Volume: 26 ISSN: 1473-0766 ISO Abbreviation: Gynecol. Endocrinol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-14 Completed Date: 2010-09-13 Revised Date: 2013-05-28 |
Medline Journal Info:
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Nlm Unique ID: 8807913 Medline TA: Gynecol Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 505-8 Citation Subset: IM |
Affiliation:
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Department of Infertility and Reproductive Medicine, Istanbul German Hospital, Istanbul, Turkey. mustafabahceci@bahceci.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Bromocriptine / therapeutic use* Databases, Factual Dopamine Agonists / therapeutic use Ergolines / therapeutic use* Female Humans Hyperprolactinemia / complications, drug therapy* Infertility, Female / complications, therapy* Pregnancy Pregnancy Rate Retrospective Studies Sperm Injections, Intracytoplasmic* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Dopamine Agonists; 0/Ergolines; 25614-03-3/Bromocriptine; LL60K9J05T/cabergoline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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