Document Detail

Comparison of c-Fos immunoreactivity in pancreatic beta cells and cells with neural crest, endoderm and mesoderm origin in rats.
MedLine Citation:
PMID:  15279077     Owner:  NLM     Status:  MEDLINE    
AIMS: Pancreatic beta cells are known to share many similarities with neuronal cells, but their origin remains controversial. It has been hypothesized that pancreatic beta cells are derived from neural crest cells. The aim of this study was to investigate the similarities between pancreatic beta cells and cells with neural crest, endoderm and mesoderm origin with respect to c-Fos immunoreactivity (c-Fos-ir), which has a role in important cellular processes including cellular proliferation, growth, differentiation and apoptosis. METHODS: c-Fos-ir was analyzed by immunohistochemical methods in formaline-fixed, paraffin-embedded sections of rat pancreatic beta cells (BCs), in adrenal medullary chromaffin cells (CCs) that are derived from neural crest, in exocrine pancreatic acinar cells (ACs) that are derived from endoderm, and in adrenal cortex zona reticularis cells (RCs) that are derived from mesoderm. RESULTS: The statistical comparisons revealed no significant differences between BCs and CCs with respect to c-Fos-ir (p>0.05). However, a highly significant difference (p<0.001) with respect to c-Fos-ir both between ACs and RCs, and between these two cell types and each of the two other cell types was noted. CONCLUSIONS: As opposed to findings in cells without neural crest origin, the observed similarity between BCs and CCs with respect to c-Fos-ir, provides additional evidence for the similarity of these cells with cells derived from neural crest.
N Keklikoglu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  27     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2005-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
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MeSH Terms
Adrenal Cortex / cytology,  metabolism*
Adrenal Medulla / cytology,  metabolism*
Chromaffin Cells / cytology,  metabolism
Endoderm / cytology,  metabolism
Islets of Langerhans / cytology,  metabolism*
Mesoderm / cytology,  metabolism
Neural Crest / cytology,  metabolism*
Proto-Oncogene Proteins c-fos / metabolism*
Zona Reticularis / cytology,  metabolism
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

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