Document Detail


Comparison of c-Fos immunoreactivity in pancreatic beta cells and cells with neural crest, endoderm and mesoderm origin in rats.
MedLine Citation:
PMID:  15279077     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: Pancreatic beta cells are known to share many similarities with neuronal cells, but their origin remains controversial. It has been hypothesized that pancreatic beta cells are derived from neural crest cells. The aim of this study was to investigate the similarities between pancreatic beta cells and cells with neural crest, endoderm and mesoderm origin with respect to c-Fos immunoreactivity (c-Fos-ir), which has a role in important cellular processes including cellular proliferation, growth, differentiation and apoptosis. METHODS: c-Fos-ir was analyzed by immunohistochemical methods in formaline-fixed, paraffin-embedded sections of rat pancreatic beta cells (BCs), in adrenal medullary chromaffin cells (CCs) that are derived from neural crest, in exocrine pancreatic acinar cells (ACs) that are derived from endoderm, and in adrenal cortex zona reticularis cells (RCs) that are derived from mesoderm. RESULTS: The statistical comparisons revealed no significant differences between BCs and CCs with respect to c-Fos-ir (p>0.05). However, a highly significant difference (p<0.001) with respect to c-Fos-ir both between ACs and RCs, and between these two cell types and each of the two other cell types was noted. CONCLUSIONS: As opposed to findings in cells without neural crest origin, the observed similarity between BCs and CCs with respect to c-Fos-ir, provides additional evidence for the similarity of these cells with cells derived from neural crest.
Authors:
N Keklikoglu
Related Documents :
12781787 - Ventrally emigrating neural tube cells migrate into the developing vestibulocochlear ne...
12786777 - Müller cells express the neuronal progenitor cell marker nestin in both differentiated...
10822267 - Avian transitin expression mirrors glial cell fate restrictions during neural crest dev...
19544437 - Nicotinamide rescues human embryonic stem cell-derived neuroectoderm from parthanatic c...
1721917 - Combined effects of extracellular matrix and growth factors on nbt-ii rat bladder carci...
627557 - Metabolic properties of maintained oligodendroglia purified from brain.
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  27     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2005-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  445-8     Citation Subset:  IM    
Affiliation:
Department of Histology and Embryology, Faculty of Dentistry, Istanbul University, Istanbul, Turkey. nkeklik@istanbul.edu.tr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex / cytology,  metabolism*
Adrenal Medulla / cytology,  metabolism*
Animals
Chromaffin Cells / cytology,  metabolism
Endoderm / cytology,  metabolism
Female
Immunohistochemistry
Islets of Langerhans / cytology,  metabolism*
Mesoderm / cytology,  metabolism
Neural Crest / cytology,  metabolism*
Proto-Oncogene Proteins c-fos / metabolism*
Rats
Zona Reticularis / cytology,  metabolism
Chemical
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Postmenopausal serum androstenedione levels are associated with the calcitonin receptor gene polymor...
Next Document:  Evaluation of two replacement regimens in primary adrenal insufficiency patients. effect on clinical...