Document Detail

Comparison by meta-analysis of drug-eluting stents and bare metal stents for saphenous vein graft intervention.
MedLine Citation:
PMID:  20381656     Owner:  NLM     Status:  MEDLINE    
This meta-analysis was undertaken to assess the efficacy and safety of drug-eluting stents (DESs) compared to bare metal stents (BMSs) in saphenous vein graft (SVG) interventions. DESs decrease the risk of target vessel revascularization in native coronary arteries compared to BMSs. The ideal treatment strategy in patients with SVG disease is unknown. A search of the published reports was conducted to identify studies that compared DESs and BMSs in SVG intervention with a minimum follow-up of 6 months. A total of 19 studies (2 randomized trials and 17 registries), including 3,420 patients who had undergone SVG intervention (DESs, n = 1,489 and BMS, n = 1,931), met the selection criteria. The mean length of follow-up was 20 + or - 12 months. Using the fixed effect model, target vessel revascularization was less frequently performed in patients who had undergone SVG intervention with a DES than with a BMS (odds ratio [OR] 0.59, 95% confidence interval [CI] 0.49 to 0.72). The incidence of myocardial infarction was lower in patients with a DES than in those with a BMS (OR 0.69, 95% CI 0.49 to 0.99). No differences were found in the risk of death (OR 0.78, 95% CI 0.59 to 1.02) or stent thrombosis (OR 0.41, 95% CI 0.15 to 1.11) between the 2 groups. In conclusion, these findings support the use of DESs in SVG lesions.
Michael S Lee; Tae Yang; David E Kandzari; Jonathan M Tobis; Hsini Liao; Ehtisham Mahmud
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2010-02-20
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-12     Completed Date:  2010-06-15     Revised Date:  2010-11-23    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1076-82     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Division of Cardiology, University of California, Los Angeles, CA, USA.
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MeSH Terms
Antineoplastic Agents, Phytogenic / pharmacology
Coronary Restenosis / epidemiology,  prevention & control
Coronary Stenosis / surgery*
Drug-Eluting Stents*
Immunosuppressive Agents / pharmacology
Myocardial Infarction / epidemiology,  prevention & control
Myocardial Revascularization / methods*
Paclitaxel / pharmacology
Saphenous Vein / transplantation*
Sirolimus / pharmacology
Treatment Outcome
United States / epidemiology
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Immunosuppressive Agents; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus
Comment In:
Am J Cardiol. 2010 Nov 15;106(10):1522-4   [PMID:  21059450 ]

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