Document Detail

Comparison of bupivacaine and etidocaine in extradural blockade.
MedLine Citation:
PMID:  6362694     Owner:  NLM     Status:  MEDLINE    
In a randomized, double-blind study, 40 female patients underwent major gynaecological surgery with extradural anaesthesia provided by 0.75% bupivacaine, 0.75% bupivacaine with adrenaline 5 micrograms ml-1, 1.5% etidocaine or 1.5% etidocaine with adrenaline 5 micrograms ml-1, 20 ml in each case. In all patients the resultant blockade was suitable for intra-abdominal pelvic surgery. Mean maximum spread of analgesia was around T3/4 with all four drugs. Onset of sensory and motor block was more rapid following etidocaine than following bupivacaine. The addition of adrenaline increased the speed of onset of sensory block. Patients receiving etidocaine had a denser motor blockade than those receiving bupivacaine, and the addition of adrenaline led to an increase in the density of the motor blockade. There were no differences in the durations of motor blockade. Objective measurements of the duration of sensory blockade showed that there were no differences between the drugs and that the addition of adrenaline increased the duration of blockade. However, pain returned sooner following etidocaine than bupivacaine, and the additive effect of adrenaline was to increase this period of subjective analgesia.
C J Sinclair; D B Scott
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  56     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-03-23     Completed Date:  1984-03-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
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MeSH Terms
Acetanilides* / pharmacology
Anesthesia, Epidural*
Bupivacaine* / pharmacology
Clinical Trials as Topic
Double-Blind Method
Drug Interactions
Epinephrine / pharmacology
Etidocaine* / pharmacology
Hemodynamics / drug effects
Middle Aged
Motor Neurons
Nerve Block
Random Allocation
Surgical Procedures, Operative
Time Factors
Reg. No./Substance:
0/Acetanilides; 2180-92-9/Bupivacaine; 36637-18-0/Etidocaine; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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