| Comparison of buccal nitroglycerin and oral isosorbide dinitrate for nitrate tolerance in stable angina pectoris. | |
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MedLine Citation:
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PMID: 3933317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen patients with chronic stable angina pectoris were studied to compare the hemodynamic and antianginal effects of buccal nitroglycerin (GTN) in a dose of 3 mg administered 3 times daily and oral isosorbide dinitrate (ISDN) in a dose of 30 mg administered 4 times daily. Compared with placebo, both oral ISDN and buccal GTN treatment induced a decrease in systolic blood pressure at rest over a 5-hour period during acute but not during sustained therapy. Neither buccal GTN nor oral ISDN modified the changes in systolic blood pressure during exercise. Both treatment programs were associated with a higher exercise heart rate during acute therapy. During sustained treatment with buccal GTN, the heart rate during exercise remained greater than that during placebo throughout the 5-hour test period, but during treatment with oral ISDN, only the exercise heart rate at 1 hour was greater than that seen with placebo. Treadmill walking time to the onset of angina and to the development of moderate angina increased significantly during acute therapy with both buccal GTN and oral ISDN. The clinical efficacy of buccal GTN was maintained after 2 weeks of 3-times-daily therapy. In contrast, during 4-times-daily therapy with oral ISDN, treadmill walking time was prolonged for only 1 hour after drug administration. This investigation indicates that tolerance develops during 4-times-daily therapy with oral ISDN, but 3 times daily therapy with buccal GTN is not associated with diminished antianginal effects. |
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Authors:
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J O Parker; K A Vankoughnett; B Farrell |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 56 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1985-11-25 Completed Date: 1985-11-25 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 724-8 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / drug therapy* Drug Therapy, Combination Drug Tolerance Female Hemodynamics / drug effects Humans Isosorbide / administration & dosage, therapeutic use* Male Middle Aged Nitroglycerin / administration & dosage, therapeutic use* Physical Exertion Rest Sorbitol / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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50-70-4/Sorbitol; 55-63-0/Nitroglycerin; 652-67-5/Isosorbide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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