Document Detail

Comparison of bronchodilator response in patients with asthma and healthy subjects using spirometry and oscillometry.
MedLine Citation:
PMID:  21962091     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: Impulse oscillometry (IOS) is an effort-independent and patient-friendly pulmonary function technique, but limited data are available that correlate the bronchodilator response using spirometry and IOS in adult asthmatic and healthy subjects.
OBJECTIVE: To compare spirometry and IOS in ongoing bronchodilator response.
METHODS: The study was a prospective evaluation of patients with asthma and healthy subjects attending screening at a research unit in a university teaching hospital. Reversibility testing was carried out using standardized American Thoracic Society/European Respiratory Society (ATS/ERS) criteria after administering 400 μg salbutamol by AccuhalerTM. Impulse oscillometry measurements (resistance at 5 Hz [R5], resistance at 20 Hz [R20], reactance at 5 Hz [X5]) and spirometry (forced expiratory volume in 1 second [FEV(1)], forced vital capacity [FVC], forced expiratory flow from 25% to 75% of vital capacity [FEF(25-75)]) were recorded pre and postbronchodilator.
RESULTS: Ninety-five asthmatic and 61 healthy subjects underwent screening. Mean percent (standard error of the mean [SEM]) baseline prebronchodilator FEV(1) was 83.99 (2.23) for patients with asthma, and 99.25 (1.72) for healthy subjects. Baseline percent predicted IOS indices in the group with asthma were 162.22 (7.5) for R5; 154.73 (4.71) for R20; and 441.72 (173.86) for X5. In healthy volunteers, corresponding values were 111.01 (3.96), 127.75 (4.12), and -229.80 (125.75). R5 was the only IOS measure that showed correlation with spirometry (FEV(1)) in both groups. The mean percent (SEM) predicted postbronchodilator change in FEV(1) and R5 in patients with asthma was 6.35 (0.65) and -33.78 (4.43); correspondingly in healthy subjects it was 2.24 (0.32) and -14.91 (2.48). A negative correlation was demonstrated (r = -0.40, P < .001 between the 2 indices in patients with asthma. Linear regression modeling demonstrated that 1 unit change in %FEV(1) corresponds to a 2.5% change in %R5.
CONCLUSIONS: Low-frequency IOS as R5 and spirometry as FEV(1) correlate in patients with asthma and healthy subjects, with changes that can be predicted by linear regression.
Arun Nair; Julia Ward; Brian J Lipworth
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  107     ISSN:  1534-4436     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-22     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.
Asthma & Allergy Research Unit, Centre for Cardiovascular & Lung Biology, Ninewells Hospital & Medical School, University of Dundee, Scotland.
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