Document Detail

Comparison of broiler performance when fed diets containing event DP-3O5423-1, nontransgenic near-isoline control, or commercial reference soybean meal, hulls, and oil.
MedLine Citation:
PMID:  19038811     Owner:  NLM     Status:  MEDLINE    
DP-3Ø5423-1 (305423) is a genetically modified soybean that was produced by biolistic insertion of the gm-fad2-1 gene fragment and gm-hra genes into the germline of soybean seeds. Expression of gm-fad2-1 results in greater concentrations of oleic acid (18:1) by suppressing expression of the endogenous FAD2-1 gene, which encodes an n-6 fatty acid desaturase enzyme that catalyzes desaturation of 18:1 to linoleic acid (18:2). The GM-HRA protein expressed by the gm-hra gene is a modified version of the soybean acetolactate synthase enzyme that is used as a selectable marker during transformation. A 42-d feeding trial was conducted with broiler chickens to compare the nutritional performance of 305423 soybeans with nontransgenic soybeans. Diets were prepared using processed fractions (meal, hulls, and oil) from 305423 soybean plants. For comparison, additional diets were produced with soybean fractions obtained from a nontransgenic near-isoline (control) and nontransgenic commercial Pioneer brand varieties (93B86, 93B15, and 93M40). Diets were fed to Ross x Cobb broilers (n = 120/group, 50% male and 50% female) in 3 phases. Starter, grower, and finisher diets contained 26.5, 23, and 21.5% soybean meal, respectively. Soybean hulls and oil were added at 1.0 and 0.5%, respectively, across all diets in each phase. No statistically significant differences were observed in growth performance (BW, mortality, feed efficiency), organ yield (liver and kidney), or carcass yield (breast, thigh, leg, wing, and abdominal fat) variables between broilers consuming diets prepared with isolated fractions from 305423 or near-isoline control soybean. Additionally, all performance and carcass variables from control and 305423 soybean treatment groups fell within tolerance intervals constructed for each response variable using data from broilers fed diets prepared with reference soybean fractions. Based on the results from this study, it was concluded that 305423 soybeans were nutritionally equivalent to non-transgenic control soybeans with a comparable genetic background.
J McNaughton; M Roberts; B Smith; D Rice; M Hinds; C Sanders; R Layton; I Lamb; B Delaney
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Poultry science     Volume:  87     ISSN:  0032-5791     ISO Abbreviation:  Poult. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-28     Completed Date:  2009-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401150     Medline TA:  Poult Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2549-61     Citation Subset:  IM    
AHPharma, 116 W. Chestnut St., Salisbury, MD 21801, USA.
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MeSH Terms
Animal Feed / analysis*
Animal Nutritional Physiological Phenomena
Body Composition
Body Weight
Chickens / growth & development*
Diet / veterinary*
Kidney / anatomy & histology
Liver / anatomy & histology
Mutagenesis, Insertional
Oleic Acid / metabolism
Organ Size
Plants, Genetically Modified
Soybean Oil / pharmacology*
Soybeans* / genetics,  metabolism
Reg. No./Substance:
112-80-1/Oleic Acid; 8001-22-7/Soybean Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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