| Comparison of blood velocity measurements between ultrasound Doppler and accelerated phase-contrast MR angiography in small arteries with disturbed flow. | |
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MedLine Citation:
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PMID: 21346280 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ultrasound Doppler (UD) velocity measurements are commonly used to quantify blood flow velocities in vivo. The aim of our work was to investigate the accuracy of in vivo spectral Doppler measurements of velocity waveforms. Waveforms were derived from spectral Doppler signals and corrected for intrinsic spectral broadening errors by applying a previously published algorithm. The method was tested in a canine aneurysm model by determining velocities in small arteries (3-4 mm diameter) near the aneurysm where there was moderately disturbed flow. Doppler results were compared to velocity measurements in the same arteries acquired with a rapid volumetric phase contrast MR angiography technique named phase contrast vastly undersampled isotropic projection reconstruction magnetic resonance angiography (PC-VIPR MRA). After correcting for intrinsic spectral broadening, there was a high degree of correlation between velocities obtained by the real-time UD and the accelerated PC-MRA technique. The peak systolic velocity yielded a linear correlation coefficient of r = 0.83, end diastolic velocity resulted in r = 0.81, and temporally averaged mean velocity resulted in r = 0.76. The overall velocity waveforms obtained by the two techniques were also highly correlated (r = 0.89 ± 0.06). There were, however, only weak correlations for the pulsatility index (PI: 0.25) and resistive index (RI: 0.14) derived from the two techniques. Results demonstrate that to avoid overestimations of peak systolic velocities, the results for UD must be carefully corrected to compensate for errors caused by intrinsic spectral broadening. |
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Authors:
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Jingfeng Jiang; Charles Strother; Kevin Johnson; Sara Baker; Dan Consigny; Oliver Wieben; James Zagzebski |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article Date: 2011-02-23 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-02 Completed Date: 2011-06-16 Revised Date: 2011-09-22 |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1755-73 Citation Subset: IM |
Affiliation:
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Medical Physics Department, University of Wisconsin-Madison School of Medicine and Public Health, WI, USA. jjiang2@wisc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acceleration Aneurysm / pathology, radiography*, veterinary Angiography, Digital Subtraction / methods Animals Arteries / physiology* Artifacts Blood Flow Velocity / physiology*, veterinary Contrast Media Dogs Female Imaging, Three-Dimensional Magnetic Resonance Angiography / methods* Ultrasonography, Doppler / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL072260-06/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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