Document Detail

Comparison of blood pressure response to exogenous epinephrine in hypertensive men and women.
MedLine Citation:
PMID:  3376888     Owner:  NLM     Status:  MEDLINE    
This study investigated possible differences between hypertensive men and hypertensive women concerning the hemodynamic effects of incremental doses of exogenous epinephrine. The study population comprised 38 men (37 +/- 10 years) (standard deviation) and 25 women (33 +/- 9 years) with mild essential hypertension (mean blood pressure 147/90 and 147/93 mm Hg, respectively). Body mass index was slightly higher in men (25 +/- 3 kg/m2) than in women (23 +/- 2 kg/m2). Both groups received an intravenous infusion with epinephrine of 15 and 30 ng/kg/min for 8 minutes each. Despite the similar doses of epinephrine infused in both groups, the increase of venous plasma epinephrine in men was nearly twice that in women (1.04 +/- 0.09 vs 0.67 +/- 0.09 nmol/liter, p less than 0.01), suggesting that women cleared the infused epinephrine more efficiently than men. At the highest infusion dose, the increase of systolic blood pressure was larger in men than in women (5.3 +/- 1.2 vs 1.7 +/- 1.1 mm Hg, p less than 0.05). Conversely, the decrease of diastolic blood pressure was also larger in men than in women (-8.8 +/- 1.0 vs -5.8 +/- 1.0 mm Hg, p less than 0.05). The heart rate increased to the same extent in both groups (11.5 +/- 0.8 and 13.7 +/- 1.2 beats/min). If the blood pressure responses were corrected for the increase of plasma epinephrine, the difference between men and women disappeared.(ABSTRACT TRUNCATED AT 250 WORDS)
J W Lenders; T De Boo; W A Lemmens; J Reijenga; J J Willemsen; T Thien
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  61     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-06-24     Completed Date:  1988-06-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1288-91     Citation Subset:  AIM; IM    
Department of Internal Medicine, St. Radboud University Hospital, Nijmegen, The Netherlands.
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MeSH Terms
Blood Pressure / drug effects*
Body Weight
Catecholamines / blood
Epinephrine / pharmacology*
Forearm / blood supply
Heart Rate / drug effects
Hypertension / blood,  physiopathology*
Regional Blood Flow / drug effects
Sex Characteristics*
Reg. No./Substance:
0/Catecholamines; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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