Document Detail

Comparison of blood pressure, heart rate and activity between normotensive and spontaneously-hypertensive rats.
MedLine Citation:
PMID:  7924636     Owner:  NLM     Status:  MEDLINE    
Blood pressure, heart rate and physical activity in spontaneously hypertensive rats (SHR) were measured and compared with those of Wistar Kyoto rats (WKY) to see how these parameters vary with age and whether we can find a marker of essential hypertension among these variables. An automatic telemetric system was employed to measure these variables. In SHR, blood pressure and physical activity increased with age, but heart rate decreased. In WKY, neither blood pressure nor physical activity showed significant changes, but heart rate decreased with age. The 24h mean values of blood pressure, heart rate and physical activity were significantly higher in SHR than in WKY. The mean values of blood pressure, heart rate and physical activity were higher during nighttime than during daytime in both SHR and WKY. Circadian MESOR and amplitude of blood pressure increased simultaneously in SHR. These results are compatible with the concept that an increased amplitude of blood pressure may predict subsequent development of essential hypertension.
I Kohno; H Honma; T Nakamura; K Tamura
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chronobiologia     Volume:  21     ISSN:  0390-0037     ISO Abbreviation:  Chronobiologia     Publication Date:    1994 Jan-Jun
Date Detail:
Created Date:  1994-10-28     Completed Date:  1994-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0434557     Medline TA:  Chronobiologia     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  45-56     Citation Subset:  IM    
Second Department of Internal Medicine, Yamanashi Medical College, Japan.
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MeSH Terms
Aging / physiology
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm / physiology*
Heart Rate / physiology*
Hypertension / physiopathology*
Motor Activity / physiology
Rats, Inbred SHR
Rats, Inbred WKY

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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