Document Detail

Comparison of biokinetics and biliary imaging parameters of four Tc-99m iminodiacetic acid derivatives in normal subjects.
MedLine Citation:
PMID:  6825355     Owner:  NLM     Status:  MEDLINE    
The biokinetics (blood clearance, urinary excretion, hepatic peak time, uptake, and excretion t-1/2) and the imaging parameters (the time of appearance of the common bile duct, gallbladder, and duodenum) were determined in 34 normal subjects using Tc-99m diethyl (EIDA), Tc-99m dimethyl (HIDA), Tc-99m paraisopropyl (PIPIDA), and Tc-99m parabutyl (PBIDA) iminodiacetic acid derivatives. The blood and hepatic clearance of the four agents were significantly different (P less than 0.05) from each other. The 24-hour urinary excretion of PBIDA was significantly lower (P less than 0.05) than the urinary excretion of the other three agents. There was no difference among the four agents in the time of appearance of the gallbladder and duodenum. The time of appearance of the common bile duct was significantly delayed with PBIDA. The maximum intensity of the common bile duct usually occurred between 20 to 40 minutes with all four agents. However, gallbladder intensity continued to increase up to 3 hours. It is concluded that in the presence of normal liver function, all four Tc-99m IDA agents show definite differences in biokinetics but these differences do not have a major effect on biliary imaging parameters. If imaging alone is the primary goal, the selection of any one of the four agents will meet the clinican's need satisfactorily.
V V Bobba; G T Krishnamurthy; E Kingston; P H Brown; M Eklem; F E Turner
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  8     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-04-15     Completed Date:  1983-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  70-5     Citation Subset:  IM    
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MeSH Terms
Common Bile Duct / metabolism,  radionuclide imaging
Duodenum / metabolism,  radionuclide imaging
Gallbladder / metabolism,  radionuclide imaging
Imino Acids / metabolism*
Liver / metabolism,  radionuclide imaging
Metabolic Clearance Rate
Middle Aged
Organotechnetium Compounds*
Technetium / metabolism*
Technetium Tc 99m Diethyl-iminodiacetic Acid
Technetium Tc 99m Lidofenin
Reg. No./Substance:
0/Imino Acids; 0/Organotechnetium Compounds; 0/Technetium Tc 99m Diethyl-iminodiacetic Acid; 0/Technetium Tc 99m Lidofenin; 0/technetium Tc 99m (para-butyl)iminodiacetic acid; 0/technetium Tc 99m PIPIDA; 7440-26-8/Technetium

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