| Comparison of biokinetics and biliary imaging parameters of four Tc-99m iminodiacetic acid derivatives in normal subjects. | |
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MedLine Citation:
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PMID: 6825355 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biokinetics (blood clearance, urinary excretion, hepatic peak time, uptake, and excretion t-1/2) and the imaging parameters (the time of appearance of the common bile duct, gallbladder, and duodenum) were determined in 34 normal subjects using Tc-99m diethyl (EIDA), Tc-99m dimethyl (HIDA), Tc-99m paraisopropyl (PIPIDA), and Tc-99m parabutyl (PBIDA) iminodiacetic acid derivatives. The blood and hepatic clearance of the four agents were significantly different (P less than 0.05) from each other. The 24-hour urinary excretion of PBIDA was significantly lower (P less than 0.05) than the urinary excretion of the other three agents. There was no difference among the four agents in the time of appearance of the gallbladder and duodenum. The time of appearance of the common bile duct was significantly delayed with PBIDA. The maximum intensity of the common bile duct usually occurred between 20 to 40 minutes with all four agents. However, gallbladder intensity continued to increase up to 3 hours. It is concluded that in the presence of normal liver function, all four Tc-99m IDA agents show definite differences in biokinetics but these differences do not have a major effect on biliary imaging parameters. If imaging alone is the primary goal, the selection of any one of the four agents will meet the clinican's need satisfactorily. |
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Authors:
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V V Bobba; G T Krishnamurthy; E Kingston; P H Brown; M Eklem; F E Turner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 8 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-04-15 Completed Date: 1983-04-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 70-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Common Bile Duct / metabolism, radionuclide imaging Duodenum / metabolism, radionuclide imaging Female Gallbladder / metabolism, radionuclide imaging Half-Life Humans Imino Acids / metabolism* Kinetics Liver / metabolism, radionuclide imaging Male Metabolic Clearance Rate Middle Aged Organotechnetium Compounds* Technetium / metabolism* Technetium Tc 99m Diethyl-iminodiacetic Acid Technetium Tc 99m Lidofenin |
| Chemical | |
Reg. No./Substance:
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0/Imino Acids; 0/Organotechnetium Compounds; 0/Technetium Tc 99m Diethyl-iminodiacetic Acid; 0/Technetium Tc 99m Lidofenin; 0/technetium Tc 99m (para-butyl)iminodiacetic acid; 0/technetium Tc 99m PIPIDA; 7440-26-8/Technetium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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