Document Detail


Comparison of biochemical simulations using integrators derived from "Adomian" decomposition with traditional numerical methods.
MedLine Citation:
PMID:  2082915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Comparisons are made between some traditional numerical integrators and integration using "Adomian" power series solutions to the ordinary differential equations. These are initial investigations to determine the viability of their application to the simulation of large complex metabolic pathways. A small set of test equations was employed to represent the types of problems encountered in biochemical applications. It was found that the "Adomian" method is as accurate as the numerical methods and, for 'nonstiff' equations or for small simulation times, the "Adomian" method is often more efficient. The results suggest that it may be worthwhile refining this method for biochemical simulations for situations where the traditional numerical methods fail.
Authors:
B T Bulliman; P W Kuchel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  49     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-08     Completed Date:  1991-05-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  661-70     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Sydney, NSW, Australia.
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MeSH Terms
Descriptor/Qualifier:
Computer Simulation
Enzymes / chemistry
Evaluation Studies as Topic
Kinetics
Mathematics
Metabolism*
Models, Biological*
Chemical
Reg. No./Substance:
0/Enzymes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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