Document Detail

Comparison of biochemical markers and cervical length for predicting preterm delivery.
MedLine Citation:
PMID:  18834339     Owner:  NLM     Status:  MEDLINE    
AIM: To examine the clinical utility of several prognostic factors for predicting preterm delivery. METHODS: One hundred and nineteen patients with a singleton pregnancy admitted to our hospital because of symptoms of preterm labor were included in this study. Maternal serum C-reactive protein (CRP), transvaginal sonographic measurement of cervical length (CL), granulocyte elastase (EL) in cervical secretions, fetal fibronectin (fFN), alpha-fetoprotein (AFP), and insulin-like growth factor binding protein-1 (IGFBP-1) in vaginal secretions were examined on admission. EL, fFN, AFP, and IGFBP-1 were measured by bed-side test kits. Correlation between each factor and the duration of pregnancy (from admission to delivery) was investigated. RESULTS: A significant correlation was found between the duration of pregnancy and CRP (r= -0.37, P<0.001), but not CL. The duration was significantly shorter in the fFN-positive group than in the negative group (P=0.0015). However, no significant difference was observed between the positive group and the negative group for each of CL, EL, AFP and IGFBP-1. CONCLUSION: Association between the duration of the pregnancy and two biochemical markers (CRP and fFN) was confirmed. As they can be examined quickly and easily, they are quite useful for estimating prognosis of preterm labor.
Sorahiro Sunagawa; Kimiyo Takagi; Kyoko Ono; Keiko Miyachi; Akihiko Kikuchi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  34     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2008-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  812-9     Citation Subset:  IM    
Department of Obstetrics, Center for Perinatal Medicine, Nagano Children's Hospital, Azumino, Nagano, Japan.
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MeSH Terms
Biological Markers / metabolism
Case-Control Studies
Cervix Uteri / anatomy & histology,  ultrasonography*
Infant, Newborn
Obstetric Labor, Premature / diagnosis*,  metabolism,  pathology
Retrospective Studies
Young Adult
Reg. No./Substance:
0/Biological Markers

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