Document Detail

Comparison between thallium-201, technetium-99m-sestamibi and technetium-99m-teboroxime planar myocardial perfusion imaging in detection of coronary artery disease.
MedLine Citation:
PMID:  1534575     Owner:  NLM     Status:  MEDLINE    
Technetium-99m-sestamibi (MIBI) and 99mTc-teboroxime (TEBO) are two new myocardial perfusion imaging agents. The purpose of this prospective study was to compare MIBI and TEBO to 201TI planar imaging. Eighteen patients with significant coronary artery disease on coronary angiogram were submitted to three treadmill stress tests performed within 3 mo and were imaged with the three radiopharmaceuticals as follows. 1. TI: 2.2 mCi, immediate and delayed views (4 hr later, 8 min/view). 2. TEBO: 15-20 mCi at stress (1 min/view) and a second injection was repeated 4 hr later at rest (20-25 mCi). 3. MIBI: 15-18 mCi at stress (8 min/view) and 1-4 days later, 15-18 mCi at rest. Patients achieved similar levels of exercise. A blinded reading was performed by three observers. The left ventricle was divided into three segments/view and ischemic/normal wall ratios were also determined. Segmental comparison showed an agreement in 85% (138/162) of the segments between TI and TEBO, in 92% (149/162) between TI and MIBI and in 84% (136/162) between MIBI and TEBO. Abnormal TI, MIBI and TEBO studies were seen in 16 (89%), 16 (89%) and 15 (83%) patients, respectively, detecting 77, 75 and 65 abnormal segments. Ischemic-to-normal wall ratios were 0.75 +/- 0.06, 0.73 +/- 0.08 and 0.78 +/- 0.08 for TI, MIBI and TEBO, respectively. In conclusion, although the biologic characteristics of these agents are different, this study showed a good correlation between them in detection of significant coronary artery disease (high pretest likelihood population).
R Taillefer; R Lambert; R Essiambre; D C Phaneuf; J Léveillé
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  33     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-06     Completed Date:  1992-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1091-8     Citation Subset:  IM    
Department of Nuclear Medicine, Hôpital Hôtel-Dieu de Montréal, Université de Montréal, Canada.
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MeSH Terms
Coronary Disease / epidemiology,  radionuclide imaging*
Heart / radionuclide imaging*
Middle Aged
Organotechnetium Compounds / diagnostic use*
Oximes / diagnostic use*
Prospective Studies
Technetium Tc 99m Sestamibi
Thallium Radioisotopes / diagnostic use*
Reg. No./Substance:
0/Organotechnetium Compounds; 0/Oximes; 0/Thallium Radioisotopes; 104716-22-5/technetium Tc 99m teboroxime; 109581-73-9/Technetium Tc 99m Sestamibi

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