| Comparison between taxane-based chemotherapy with conventional surgery-based therapy for cutaneous angiosarcoma: a single center experience. | |
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MedLine Citation:
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PMID: 23210914 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Objective To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma. Methods A case-control study comparing patients who received taxanes without wide local excision (group A, n=5) and patients who received conventional surgery-based therapy (group B, n=8) in one university hospital in eastern Japan. Data were collected from a total of 13 patients with cutaneous angiosarcoma treated from November 1997 through July 2009. Results Group A received taxanes: 4 patients received docetaxel, and 1 patient received paclitaxel. Radiation was used concomitantly in 2 patients. Marginal local excision was performed in 2 patients. Group B received wide local excision followed by radiation (6 patients), docetaxel (3 patients), and interleukin-2 (2 patients). No patients in group A had local recurrence, whereas 5 out of the 8 patients in group B did (P<0.05, chi-square test). Median overall survival was 31 months in group A, 10 months in group B. Estimated overall survival using the Kaplan-Meier method was significantly longer in group A (P<0.05, log-rank test). Conclusion In our series, taxane-based chemotherapy was superior to conventional surgery-based therapy. Our results indicated that taxane regimens without mutilating surgery offered both local control and prevention of metastasis, which led to prolonged survival. |
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Authors:
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Yasuhiro Fujisawa; Yasuhiro Nakamura; Yasuhiro Kawachi; Fujio Otsuka |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-5 |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: - ISSN: 1471-1753 ISO Abbreviation: J Dermatolog Treat Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Dermatlogy, University of Tsukuba. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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