Document Detail


Comparison between taxane-based chemotherapy with conventional surgery-based therapy for cutaneous angiosarcoma: a single center experience.
MedLine Citation:
PMID:  23210914     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Objective To show the efficacy of taxane-based chemotherapy for the treatment of cutaneous angiosarcoma. Methods A case-control study comparing patients who received taxanes without wide local excision (group A, n=5) and patients who received conventional surgery-based therapy (group B, n=8) in one university hospital in eastern Japan. Data were collected from a total of 13 patients with cutaneous angiosarcoma treated from November 1997 through July 2009. Results Group A received taxanes: 4 patients received docetaxel, and 1 patient received paclitaxel. Radiation was used concomitantly in 2 patients. Marginal local excision was performed in 2 patients. Group B received wide local excision followed by radiation (6 patients), docetaxel (3 patients), and interleukin-2 (2 patients). No patients in group A had local recurrence, whereas 5 out of the 8 patients in group B did (P<0.05, chi-square test). Median overall survival was 31 months in group A, 10 months in group B. Estimated overall survival using the Kaplan-Meier method was significantly longer in group A (P<0.05, log-rank test). Conclusion In our series, taxane-based chemotherapy was superior to conventional surgery-based therapy. Our results indicated that taxane regimens without mutilating surgery offered both local control and prevention of metastasis, which led to prolonged survival.
Authors:
Yasuhiro Fujisawa; Yasuhiro Nakamura; Yasuhiro Kawachi; Fujio Otsuka
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  The Journal of dermatological treatment     Volume:  -     ISSN:  1471-1753     ISO Abbreviation:  J Dermatolog Treat     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8918133     Medline TA:  J Dermatolog Treat     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Dermatlogy, University of Tsukuba.
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