Document Detail

Comparison between the sublingual and oral route of misoprostol for pre-abortion cervical priming in first trimester abortions.
MedLine Citation:
PMID:  14688160     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Misoprostol has been used for achieving cervical priming before suction evacuation (SE) by the oral or vaginal route, although both routes have their shortcomings. We evaluated the efficacy of the sublingual versus oral route of misoprostol for cervical priming before SE. METHODS: A prospective clinical trial was carried out in 100 women with a period of gestation of between 6 and 12 weeks who were sequentially allocated to two groups of 50 each. Both groups received 400 microg of misoprostol 3 h prior to SE by either the sublingual or the oral route. RESULTS: Demographically, both groups were similar. For all periods of gestation, sublingual misoprostol significantly improved cervical dilation (P<0.001) with a reduction in duration of surgery (P=0.024) compared with the oral route. Mean (+/- SD) pain scores for the sublingual and oral groups were similar (2.6 +/- 1.4 versus 3.5 +/- 1.1). No major complications occurred in either of the two groups. CONCLUSION: the sublingual route is an effective alternative to oral administration of misoprostol for cervical dilation. To the best of our knowledge, this is the first study to compare the efficacy of the sublingual versus the oral route of misoprostol for cervical priming before SE.
Pikee Saxena; Sudha Salhan; Nivedita Sarda
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  19     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2003-12-22     Completed Date:  2004-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  77-80     Citation Subset:  IM    
Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*
Abortion, Induced*
Administration, Oral
Administration, Sublingual
Cervical Ripening*
Misoprostol / administration & dosage*
Pregnancy Trimester, First
Preoperative Care*
Single-Blind Method
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

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