Document Detail


Comparison between sirolimus- and paclitaxel-eluting stent in T-cell subsets redistribution.
MedLine Citation:
PMID:  16461044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We sought to investigate the effects of 2 different coronary drug-eluting stents on the distribution of central or effector memory T cells circulating in the coronary sinus of patients with coronary artery disease who underwent percutaneous coronary revascularization. We randomly assigned 43 patients (mean age 65.4 +/- 4.3 years; 34 men) presenting with stable coronary disease and angiographically proved stenosis of the left anterior descending artery to treatment with sirolimus- or paclitaxel-eluting stents. Heparinized blood samples were obtained from the coronary sinus before and 20 minutes after stent implantation. Analysis of surface phenotype was performed by 4-color flow cytometry, and data are expressed as the percentage of positive cells. The percentages of CD8+ and CD4+ effector memory T cells, as defined by the CD3+CD45RO+CD27- phenotype, were significantly reduced in patients who received a sirolimus-eluting stent compared with the basal values. Conversely, the percentages of CD8+, but not CD4+, central memory T cells (CD3+CD45RO+CD27+) were increased in the same treatment group after the revascularization procedure. No changes in the percentages of memory T-cell populations in the paclitaxel-eluting stent group were observed. These findings show that sirolimus-eluting stents rapidly induced a redistribution of memory T lymphocytes, with a significant decrease of proinflammatory effector memory T cells circulating within the coronary sinus.
Authors:
Gennaro Sardella; Leonardo De Luca; Angelo Di Roma; Giovanni De Persio; Giulia Conti; Marino Paroli; Francesco Fedele
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2006-01-04
Journal Detail:
Title:  The American journal of cardiology     Volume:  97     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-03-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-8     Citation Subset:  AIM; IM    
Affiliation:
Dipartimento di Scienze Cardiovascolari e Respiratorie, Università La Sapienza, Rome, Italy. rino.sardella@uniroma1.it
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MeSH Terms
Descriptor/Qualifier:
Aged
CD4-Positive T-Lymphocytes / physiology
CD8-Positive T-Lymphocytes / physiology
Coronary Disease / immunology,  therapy*
Female
Flow Cytometry
Humans
Immunosuppressive Agents / administration & dosage*
Male
Middle Aged
Paclitaxel / administration & dosage*
Sirolimus / administration & dosage*
Stents*
T-Lymphocyte Subsets / physiology*
Chemical
Reg. No./Substance:
0/Immunosuppressive Agents; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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