| Comparison between nifedipine and carvedilol in the treatment of de novo arterial hypertension after liver transplantation: preliminary results of a controlled clinical trial. | |
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MedLine Citation:
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PMID: 15848684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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There is no controlled clinical trial on the treatment of de novo arterial hypertension after liver transplantation (LT) a common complication using calcineurin inhibitors (CNI) for immunosuppressive therapy. The aim of this study was to compare the efficacy and safety of nifedipine, a calcium channel blocker, and carvedilol, an alpha1- and beta-blocker. The study included 50 patients who developed arterial hypertension after LT. The data on the first 30 patients who have completed 12-month follow-up are reported herein. Eighteen patients received nifedipine, and 12 patients received carvedilol. Patients were evaluated monthly at the outpatient clinic for 1 year. If patients developed severe adverse effects to nifedipine, they were switched to carvedilol and vice versa (therapy failure). The two groups were similar for clinical features, indications for LT, immunosuppressive therapy, and baseline blood pressures. A failure of treatment was observed in 9 of 18 patients treated with nifedipine (50.0%) and one of 12 patients treated with carvedilol (8%, P < .025). Nifedipine was effective in 4 of 18 patients, carvedilol, in 4 of 12 patients (22.21% vs 33.3%, P = NS). Two of the nine nonresponders to nifedipine responded to carvedilol. The efficacy of monotherapy was observed in 11 of 40 randomized patients (27.5%). Carvedilol monotherapy is as effective as nifedipine but far better tolerated. |
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Authors:
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A Galioto; P Angeli; S Guarda; P Burra; G Zanus; S Fasolato; S Fagiuoli; A Sticca; A Semplicini; M Sartori; A Carraro; P Boccagni; U Cillo; A Gatta |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Transplantation proceedings Volume: 37 ISSN: 0041-1345 ISO Abbreviation: Transplant. Proc. Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-04-25 Completed Date: 2005-09-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
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Languages: eng Pagination: 1245-7 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy. alegalioto@libero.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure Carbazoles / therapeutic use* Female Heart Rate Humans Hypertension / drug therapy* Liver Transplantation* Male Middle Aged Nifedipine / therapeutic use* Propanolamines / therapeutic use* Treatment Outcome Vasodilator Agents / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Carbazoles; 0/Propanolamines; 0/Vasodilator Agents; 21829-25-4/Nifedipine; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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