Document Detail


Comparison between nifedipine and carvedilol in the treatment of de novo arterial hypertension after liver transplantation: preliminary results of a controlled clinical trial.
MedLine Citation:
PMID:  15848684     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is no controlled clinical trial on the treatment of de novo arterial hypertension after liver transplantation (LT) a common complication using calcineurin inhibitors (CNI) for immunosuppressive therapy. The aim of this study was to compare the efficacy and safety of nifedipine, a calcium channel blocker, and carvedilol, an alpha1- and beta-blocker. The study included 50 patients who developed arterial hypertension after LT. The data on the first 30 patients who have completed 12-month follow-up are reported herein. Eighteen patients received nifedipine, and 12 patients received carvedilol. Patients were evaluated monthly at the outpatient clinic for 1 year. If patients developed severe adverse effects to nifedipine, they were switched to carvedilol and vice versa (therapy failure). The two groups were similar for clinical features, indications for LT, immunosuppressive therapy, and baseline blood pressures. A failure of treatment was observed in 9 of 18 patients treated with nifedipine (50.0%) and one of 12 patients treated with carvedilol (8%, P < .025). Nifedipine was effective in 4 of 18 patients, carvedilol, in 4 of 12 patients (22.21% vs 33.3%, P = NS). Two of the nine nonresponders to nifedipine responded to carvedilol. The efficacy of monotherapy was observed in 11 of 40 randomized patients (27.5%). Carvedilol monotherapy is as effective as nifedipine but far better tolerated.
Authors:
A Galioto; P Angeli; S Guarda; P Burra; G Zanus; S Fasolato; S Fagiuoli; A Sticca; A Semplicini; M Sartori; A Carraro; P Boccagni; U Cillo; A Gatta
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Transplantation proceedings     Volume:  37     ISSN:  0041-1345     ISO Abbreviation:  Transplant. Proc.     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-04-25     Completed Date:  2005-09-26     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0243532     Medline TA:  Transplant Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1245-7     Citation Subset:  IM    
Affiliation:
Department of Clinical and Experimental Medicine, University of Padua, Padova, Italy. alegalioto@libero.it
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure
Carbazoles / therapeutic use*
Female
Heart Rate
Humans
Hypertension / drug therapy*
Liver Transplantation*
Male
Middle Aged
Nifedipine / therapeutic use*
Propanolamines / therapeutic use*
Treatment Outcome
Vasodilator Agents / therapeutic use*
Chemical
Reg. No./Substance:
0/Carbazoles; 0/Propanolamines; 0/Vasodilator Agents; 0K47UL67F2/carvedilol; 21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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