| Comparison between local ablative therapy and chemotherapy for non-resectable colorectal liver metastases: a prospective study. | |
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MedLine Citation:
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PMID: 17195903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is a growing interest for the use of local ablative techniques in patients with non-resectable colorectal liver metastases. Evidence on the efficacy over systemic chemotherapy is, however, extremely weak. In this prospective study we aim to assess the additional benefits of local tumour ablation. METHODS: A consecutive series of 201 colorectal cancer patients, without extrahepatic disease, that underwent laparotomy for surgical treatment of liver metastases, were prospectively followed for survival and HRQoL. At laparotomy three groups were identified: patients in whom radical resection of metastases proved feasible, patients in whom resection was not feasible and received local ablative therapy, and patients in whom resection or local ablation was not feasible for technical reasons and who received systemic chemotherapy. FINDINGS: Patients in the chemotherapy and in local ablation group were comparable for all prognostic variables tested. For the local ablation group overall survival at 2 and 5 years was 56 and 27%, respectively (median 31 months, n = 45), for the chemotherapy group 51 and 15%, respectively (median 26 months, n = 39) (P = 0.252). After resection these figures were 83 and 51%, respectively (median 61 months, n = 117) (P < 0.001). The median DFS after local ablation was 9 months, HRQoL was restored within 3 months. Patients after local ablation gained far more QALY's (317) than in the chemotherapy group (165) (P < 0.001). INTERPRETATION: Although overall survival did not reached statistical significance, the median DFS of 9 months suggests a beneficial effect of local tumour ablation for non-resectable colorectal liver metastases. Moreover, compared with systemic chemotherapy more QALY's were gained after local ablative therapy. |
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Authors:
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Theo J M Ruers; Joris J Joosten; Bastiaan Wiering; Barbara S Langenhoff; Heleen M Dekker; Theo Wobbes; Wim J G Oyen; Paul F M Krabbe; Cornelis J A Punt |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-12-31 |
Journal Detail:
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Title: Annals of surgical oncology Volume: 14 ISSN: 1068-9265 ISO Abbreviation: Ann. Surg. Oncol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-09 Completed Date: 2007-06-12 Revised Date: 2007-07-18 |
Medline Journal Info:
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Nlm Unique ID: 9420840 Medline TA: Ann Surg Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1161-9 Citation Subset: IM |
Affiliation:
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Department of Surgery, Division of Surgical Oncology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands. T.Ruers@chir.umcn.nl |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Catheter Ablation* Colorectal Neoplasms / pathology, therapy* Combined Modality Therapy / methods Cryotherapy Female Follow-Up Studies Humans Laparotomy Liver Neoplasms / secondary*, therapy* Male Middle Aged Neoplasm Recurrence, Local / therapy Neoplasm Staging / methods Patient Selection Preoperative Care / methods Prospective Studies Quality of Life Survival Rate Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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