Document Detail

Comparison between invasive and non-invasive measurements of baroreflex sensitivity; implications for studies on risk stratification after a myocardial infarction.
MedLine Citation:
PMID:  10973766     Owner:  NLM     Status:  MEDLINE    
AIMS: The ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) study has proved the independent prognostic value of baroreflex sensitivity. A limitation of the traditional method of estimating baroreflex sensitivity by phenylephrine, is the need to monitor intra-arterial blood pressure. Our objective was to establish whether this invasive method of monitoring could be superseded by non-invasive methods, such as the Finapres device. METHODS AND RESULTS: Patients with three repeated invasive and non-invasive baroreflex sensitivity measurements were selected from the ATRAMI database (n = 454). The mean of these measurements was taken as the baroreflex sensitivity estimate. The repeatability of both methods (standard deviation of the three measurements) decreased with increasing baroreflex sensitivity. There was no constant bias between invasive and non-invasive measurements (0. 22+/-2.2 ms. mmHg(-1), P = 0.42). The linear correlation was very high (r = 0.91, P < 0.01). The normalized 95% limits of agreement were -0.5 and 0.52. On survival analysis, invasive and non-invasive baroreflex sensitivity gave similar prognostic information (likelihood ratio: 155.6 (P = 0.007) and 155.0 (P = 0.006); risk ratio: 0.79 and 0.81, respectively). According to the ATRAMI cut-off points, 85% of patients were classified concordantly by the two methods. None of the patients at high (low) risk with the invasive method were classified as low (high) risk class by the non-invasive method. CONCLUSION: Despite wide limits of agreement, invasive and non-invasive baroreflex sensitivity measurements are highly correlated and provide equivalent prognostic information.
G D Pinna; M T La Rovere; R Maestri; A Mortara; J T Bigger; P J Schwartz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European heart journal     Volume:  21     ISSN:  0195-668X     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-12-07     Completed Date:  2000-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1522-9     Citation Subset:  IM    
Copyright Information:
Copyright 2000 The European Society of Cardiology.
Department of Biomedical Engineering, S. Maugeri Foundation, Institute of Care and Scientific Research, Rehabilitation Institute of Montescano, Pavia, Italy.
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MeSH Terms
Autonomic Nervous System / physiopathology*
Baroreflex / physiology*
Data Interpretation, Statistical
Middle Aged
Myocardial Infarction / physiopathology*
Phenylephrine / administration & dosage
Predictive Value of Tests
Reproducibility of Results
Sensitivity and Specificity
Signal Processing, Computer-Assisted
Vasoconstrictor Agents / administration & dosage
Reg. No./Substance:
0/Vasoconstrictor Agents; 59-42-7/Phenylephrine
Comment In:
Eur Heart J. 2000 Sep;21(18):1494-5   [PMID:  10973760 ]

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