Document Detail


Comparison between intact and bioactive parathyroid hormone assays in patients with severe heart failure.
MedLine Citation:
PMID:  23246538     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: Parathyroid hormone (PTH) is a major systemic calcium-regulating hormone. Recent evidence has suggested that measurement of PTH might provide complementary information for the diagnosis and risk stratification of patients with heart failure (HF). The aim of our study was to compare intact and bioactive PTH assays in patients with severe heart failure. Design and Methods The following measurements were carried out in blood samples from 73 patients with severe heart failure: bioactive PTH (1-84) assay, intact PTH assay, non-PTH (1-84), 25-hydroxyvitamin D, B-type natriuretic peptide (BNP), N-terminal proBNP (Nt-proBNP), Galectin-3 and high sensitive troponin T (hsTnT). RESULTS: The correlation between intact and bioactive PTH assays was very high in HF patients. However, the bioactive PTH concentrations were lower than those measured with the intact assay. Intact and bioactive PTH as well as non PTH (1-84) were significantly and positively correlated to BNP, Nt-proBNP, galectin-3 but not to hsTnT. The strongest relationships with these cardiac biomarkers and with cardiovascular death were observed with the bioactive PTH assay. CONCLUSIONS: The PTH concentrations obtained with intact and bioactive assays are not comparable in patients with severe HF. The specificity of PTH assays might therefore impact on the potential diagnosis and prognosis values of PTH testing in patients with heart failure.
Authors:
D Gruson; T Lepoutre; S A Ahn; J M Ketelslegers; M F Rousseau
Related Documents :
16940928 - Organic colonic lesions in patients with irritable bowel syndrome (ibs).
3435008 - Management of colorectal adenoma: a singapore experience.
1467908 - Evidence from dynamic integrated proctography to redefine anismus.
19858708 - Frequency of extrapancreatic neoplasms in intraductal papillary mucinous neoplasm of th...
6195958 - Zinc in multiple sclerosis.
16403408 - Myelodysplastic syndromes: iron overload consequences and current chelating therapies.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-11
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  Clin. Biochem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
Affiliation:
Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium; Department of Laboratory Medicine, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium. Electronic address: damien.gruson@uclouvain.be.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Quality assessment for clinical proteomics.
Next Document:  Comparison of Three anti-dsDNA Assays: Performance and Correlation with Systemic Lupus Erythematosus...