| Comparison between cortical distribution of I-123 iomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT. | |
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MedLine Citation:
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PMID: 10478740 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To compare brain perfusion and synaptic density in Alzheimer's disease assessed using I-123 iomazenil SPECT with brain perfusion assessed using Tc-99m HMPAO SPECT. MATERIALS AND METHODS: Early and delayed I-123 iomazenil SPECT images acquired 20 and 180 minutes after injection were compared with Tc-99m HMPAO SPECT studies acquired 15 to 20 minutes after injection in five patients with Alzheimer's disease. RESULTS: Visual analysis of I-123 iomazenil images showed more severe (n = 4) and extensive (n = 3) defects than did Tc-99m HMPAO. Semiquantitative analysis was performed by normalizing the uptake of Tc-99m HMPAO and I-123 iomazenil in individual brain regions in the cerebellum and expressing these values as a ratio of the occipital regions. The analysis of brain regional ratios in Tc-99m HMPAO studies showed a low but significant correlation with ratios of delayed (r = 0.325, P < 0.05) images in the I-123 iomazenil studies. Furthermore, when compared with Tc-99m HMPAO, early (P < 0.01) and delayed mean ratios (P < 0.05) were significantly less in the frontal regions; early mean ratios were significantly less in the temporal regions (P < 0.05), and delayed (P < 0.05) mean ratios were significantly less in the parietal regions. CONCLUSIONS: Tc-99m HMPAO images were better correlated with I-123 iomazenil images, indicating cortical synaptic density (delayed images). I-123 iomazenil SPECT in patients with Alzheimer's disease provided more sensitive information than Tc-99m HMPAO, allowing evaluation of brain perfusion and synaptic density. |
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Authors:
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A Varrone; A Soricelli; A Postiglione; M Salvatore |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical nuclear medicine Volume: 24 ISSN: 0363-9762 ISO Abbreviation: Clin Nucl Med Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-21 Completed Date: 1999-10-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 660-5 Citation Subset: IM |
Affiliation:
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The Center for Nuclear Medicine of The National Research Council, University Federico II, Naples, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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metabolism,
radionuclide imaging* Brain / metabolism* Female Flumazenil / analogs & derivatives*, diagnostic use, pharmacokinetics Humans Iodine Radioisotopes / diagnostic use, pharmacokinetics* Male Middle Aged Technetium Tc 99m Exametazime / diagnostic use, pharmacokinetics* Tomography, Emission-Computed, Single-Photon* |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 100504-35-6/Technetium Tc 99m Exametazime; 127396-36-5/iomazenil; 78755-81-4/Flumazenil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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