Document Detail

Comparison between cortical distribution of I-123 iomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT.
MedLine Citation:
PMID:  10478740     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To compare brain perfusion and synaptic density in Alzheimer's disease assessed using I-123 iomazenil SPECT with brain perfusion assessed using Tc-99m HMPAO SPECT. MATERIALS AND METHODS: Early and delayed I-123 iomazenil SPECT images acquired 20 and 180 minutes after injection were compared with Tc-99m HMPAO SPECT studies acquired 15 to 20 minutes after injection in five patients with Alzheimer's disease. RESULTS: Visual analysis of I-123 iomazenil images showed more severe (n = 4) and extensive (n = 3) defects than did Tc-99m HMPAO. Semiquantitative analysis was performed by normalizing the uptake of Tc-99m HMPAO and I-123 iomazenil in individual brain regions in the cerebellum and expressing these values as a ratio of the occipital regions. The analysis of brain regional ratios in Tc-99m HMPAO studies showed a low but significant correlation with ratios of delayed (r = 0.325, P < 0.05) images in the I-123 iomazenil studies. Furthermore, when compared with Tc-99m HMPAO, early (P < 0.01) and delayed mean ratios (P < 0.05) were significantly less in the frontal regions; early mean ratios were significantly less in the temporal regions (P < 0.05), and delayed (P < 0.05) mean ratios were significantly less in the parietal regions. CONCLUSIONS: Tc-99m HMPAO images were better correlated with I-123 iomazenil images, indicating cortical synaptic density (delayed images). I-123 iomazenil SPECT in patients with Alzheimer's disease provided more sensitive information than Tc-99m HMPAO, allowing evaluation of brain perfusion and synaptic density.
A Varrone; A Soricelli; A Postiglione; M Salvatore
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical nuclear medicine     Volume:  24     ISSN:  0363-9762     ISO Abbreviation:  Clin Nucl Med     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7611109     Medline TA:  Clin Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  660-5     Citation Subset:  IM    
The Center for Nuclear Medicine of The National Research Council, University Federico II, Naples, Italy.
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MeSH Terms
Alzheimer Disease / metabolism,  radionuclide imaging*
Brain / metabolism*
Flumazenil / analogs & derivatives*,  diagnostic use,  pharmacokinetics
Iodine Radioisotopes / diagnostic use,  pharmacokinetics*
Middle Aged
Technetium Tc 99m Exametazime / diagnostic use,  pharmacokinetics*
Tomography, Emission-Computed, Single-Photon*
Reg. No./Substance:
0/Iodine Radioisotopes; 100504-35-6/Technetium Tc 99m Exametazime; 127396-36-5/iomazenil; 78755-81-4/Flumazenil

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