| Comparison between continuous or intermittent schedules of sublingual immunotherapy for house dust mites: effects on compliance, patients satisfaction, quality of life and safety. | |
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MedLine Citation:
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PMID: 18547495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sublingual immunotherapy (SLIT) is indicated in the treatment of allergic rhinitis and asthma. However, an issue scantly investigated is the patients satisfaction and the consequent compliance. This study is aimed at evaluating the possible differences of SLIT administered continuously or intermittently on several parameters: clinical efficacy, Quality of Life (QoL), satisfaction, compliance and safety. Forty allergic patients were treated for 12 months. The treatment was carried out by sublingual administration of an allergen extract of a 50% mixture of Dermatophagoides pteronyssinus and Dermatophagoides farinae at 10 and 300 IR/ml concentrations. Patients were randomly treated continuously or intermittently (i.e. 2 month treatment alternate to 2 month suspension). Both schedules were significantly effective in reducing allergic symptoms and improving QoL. Compliance and satisfaction were good in both groups. Local and systemic reactions were few, self-resolving, and mild in both schedules. Intergroup analysis did not reveal any difference between the two groups regarding these parameters. In conclusion, this preliminary study provides the evidence that also intermittent SLIT is as effective and safe as traditional continuous treatment. In addition, compliance and satisfaction are super-imposable in the two groups. |
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Authors:
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G Cadario; G Ciprandi; G Di Cara; R Fadel; C Incorvaia; F Marcucci; F Marengo; P Puccinelli; L Sensi; L Strazzeri; F Frati |
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Publication Detail:
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Type: Comparative Study; Letter |
Journal Detail:
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Title: International journal of immunopathology and pharmacology Volume: 21 ISSN: 0394-6320 ISO Abbreviation: Int J Immunopathol Pharmacol Publication Date: 2008 Apr-Jun |
Date Detail:
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Created Date: 2008-06-12 Completed Date: 2008-09-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8911335 Medline TA: Int J Immunopathol Pharmacol Country: Italy |
Other Details:
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Languages: eng Pagination: 471-3 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Sublingual Adolescent Adult Animals Child Child, Preschool Desensitization, Immunologic* / adverse effects, psychology Female Humans Hypersensitivity / immunology*, therapy* Injections, Subcutaneous Male Middle Aged Pain Measurement Patient Compliance Patient Satisfaction Pyroglyphidae / immunology* Quality of Life Rhinitis, Allergic, Perennial / psychology, therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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