Document Detail

Comparison between continuous or intermittent schedules of sublingual immunotherapy for house dust mites: effects on compliance, patients satisfaction, quality of life and safety.
MedLine Citation:
PMID:  18547495     Owner:  NLM     Status:  MEDLINE    
Sublingual immunotherapy (SLIT) is indicated in the treatment of allergic rhinitis and asthma. However, an issue scantly investigated is the patients satisfaction and the consequent compliance. This study is aimed at evaluating the possible differences of SLIT administered continuously or intermittently on several parameters: clinical efficacy, Quality of Life (QoL), satisfaction, compliance and safety. Forty allergic patients were treated for 12 months. The treatment was carried out by sublingual administration of an allergen extract of a 50% mixture of Dermatophagoides pteronyssinus and Dermatophagoides farinae at 10 and 300 IR/ml concentrations. Patients were randomly treated continuously or intermittently (i.e. 2 month treatment alternate to 2 month suspension). Both schedules were significantly effective in reducing allergic symptoms and improving QoL. Compliance and satisfaction were good in both groups. Local and systemic reactions were few, self-resolving, and mild in both schedules. Intergroup analysis did not reveal any difference between the two groups regarding these parameters. In conclusion, this preliminary study provides the evidence that also intermittent SLIT is as effective and safe as traditional continuous treatment. In addition, compliance and satisfaction are super-imposable in the two groups.
G Cadario; G Ciprandi; G Di Cara; R Fadel; C Incorvaia; F Marcucci; F Marengo; P Puccinelli; L Sensi; L Strazzeri; F Frati
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Publication Detail:
Type:  Comparative Study; Letter    
Journal Detail:
Title:  International journal of immunopathology and pharmacology     Volume:  21     ISSN:  0394-6320     ISO Abbreviation:  Int J Immunopathol Pharmacol     Publication Date:    2008 Apr-Jun
Date Detail:
Created Date:  2008-06-12     Completed Date:  2008-09-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8911335     Medline TA:  Int J Immunopathol Pharmacol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  471-3     Citation Subset:  IM    
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MeSH Terms
Administration, Sublingual
Child, Preschool
Desensitization, Immunologic* / adverse effects,  psychology
Hypersensitivity / immunology*,  therapy*
Injections, Subcutaneous
Middle Aged
Pain Measurement
Patient Compliance
Patient Satisfaction
Pyroglyphidae / immunology*
Quality of Life
Rhinitis, Allergic, Perennial / psychology,  therapy*

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