Document Detail

Comparison between bubble CPAP and ventilator-derived CPAP in rabbits.
MedLine Citation:
PMID:  19166119     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Continuous positive airway pressure (CPAP) is used in infants with respiratory distress and apnea. Bubble CPAP (B-CPAP) and ventilator-derived CPAP (V-CPAP) are two of the most popular CPAP modes, and use different pressure sources. However, few studies have been performed to compare their differences and effectiveness. This study was to determine whether B-CPAP and V-CPAP would have different effects on vital signs and arterial blood gas analysis. METHODS: We performed a randomized crossover study to measure vital signs, including mean blood pressure (MBP), heart rate (HR), and respiratory rate (RR), in 12 ketamine-anesthetized healthy rabbits receiving endotracheal intubation by tracheostomy with B-CPAP or V-CPAP. Arterial blood was also sampled and analyzed for PaO2, PaCO2, HCO3 and pH. RESULTS: We observed statistically significant decreases in RR, pH and PaO2 with corresponding incrases in PaCO2 and HCO3 during the V-CPAP; however, no significant changes from baseline were observed for B-CPAP. Neither modality resulted in statistically significant changes in MBP or HR. Both forms of CPAP altered vital signs and arterial blood gases in a similar manner. There was a trend towards a lower percentage of change from baseline in all variables in B-CPAP compared with V-CPAP. CONCLUSIONS: Our results suggest that B-CPAP seems to be superior to V-CPAP in terms of its effect on arterial blood gases and vital signs. We speculate that B-CPAP could have certain protective effects that better preserve both arterial blood gases and vital signs when compared to V-CPAP. However, the results of this study still need to be tested by clinical study.
Wen-Chin Huang; Yi-Ming Hua; Chuen-Ming Lee; Chun-Cheng Chang; Yeong-Seng Yuh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatrics and neonatology     Volume:  49     ISSN:  1875-9572     ISO Abbreviation:  -     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-26     Completed Date:  2009-03-10     Revised Date:  2009-03-31    
Medline Journal Info:
Nlm Unique ID:  101484755     Medline TA:  Pediatr Neonatol     Country:  Singapore    
Other Details:
Languages:  eng     Pagination:  223-9     Citation Subset:  IM    
Department of Pediatrics, Tri-Service General Hospital and National Defense Medical Center, Taipei, Taiwan.
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MeSH Terms
Blood Pressure
Continuous Positive Airway Pressure / methods*
Cross-Over Studies
Heart Rate
Respiratory Physiological Phenomena
Erratum In:
Pediatr Neonatol. 2009 Feb;50(1):39

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