Document Detail


Comparison between bacampicillin and amoxycillin in treating genital and extragenital infection with Neisseria gonorrhoeae and pharyngeal infection with Neisseria meningitidis.
MedLine Citation:
PMID:  6440658     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sixty three patients presumed to have genital gonorrhoea who gave histories of extragenital sexual practices were randomly treated with amoxycillin 3 g or bacampicillin 4.8 g (equivalent to 3.5 g ampicillin) with probenecid 1 g to compare the efficacy of the drugs in treating gonorrhoea at all sites. Three patients were initially culture negative, and seven failed to return for follow up. Twenty seven of 28 patients receiving bacampicillin and all 25 receiving amoxycillin gave negative genital cultures for Neisseria gonorrhoeae five to nine days after treatment. Twenty two of 60 patients had extragenital gonorrhoea. One failed to return, but all eight who had received amoxycillin and 12 of 13 who had received bacampicillin gave negative pharyngeal and anorectal cultures after treatment. N meningitidis was isolated from the pharynx in 17 of 60 patients on initial attendance. Three of 14 were still colonised with the meningococcus after treatment. Two of 32 patients receiving amoxycillin and 12 of 31 receiving bacampicillin reported experiencing gastrointestinal side effects.
Authors:
L D Edwards; T Gartner
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The British journal of venereal diseases     Volume:  60     ISSN:  0007-134X     ISO Abbreviation:  Br J Vener Dis     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-03-05     Completed Date:  1985-03-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421042     Medline TA:  Br J Vener Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  380-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amoxicillin / therapeutic use*
Ampicillin / analogs & derivatives*,  therapeutic use
Anus Diseases / drug therapy
Bacterial Infections / drug therapy*
Drug Therapy, Combination
Female
Genital Diseases, Female / drug therapy*
Genital Diseases, Male / drug therapy*
Gonorrhea / drug therapy*
Humans
Male
Neisseria meningitidis
Pharyngeal Diseases / drug therapy*
Probenecid / therapeutic use
Random Allocation
Rectal Diseases / drug therapy
Chemical
Reg. No./Substance:
26787-78-0/Amoxicillin; 50972-17-3/bacampicillin; 57-66-9/Probenecid; 69-53-4/Ampicillin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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