| Comparison between atosiban and nicardipine in inducing hypotension during in-utero transfers for threatening premature delivery. | |
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MedLine Citation:
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PMID: 19696681 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The aim of this study was to compare the frequency of hypotension induced by oxytocin antagonist atosiban and nicardipine. METHODS: This case-control study enrolled 14 pregnant women presenting with threatening premature delivery treated with atosiban and managed by a physician-staffed Emergency Medical Service Department (French Emergency Medical Service system) during inter-hospital transfers. A control group of 42 consecutive pregnant women presenting with threatening premature delivery managed during inter-hospital transfers during the same period and treated with nicardipine was set up. The control group was recruited after matching on confounding variables: age 38 years or less and no previous cardiovascular disease to avoid factors related to the occurrence of cardiovascular events, duration of out-of-hospital management of at least 60 min to have similar likelihood of side-effect occurrence, and parity 2 or less and gestational age from 25 to 32 weeks to make comparable groups from the obstetrical viewpoint. Frequency of hypotension was compared between the two groups. RESULTS: Hypotension was observed in two patients (8%) in the atosiban-group and in five patients (14%) in the nicardipine-group, which is not significantly different (P>0.99). CONCLUSION: Despite the notion that oxytocin antagonist atosiban has limited or no systemic adverse effects, these results suggest that this cost-consuming drug does not avoid hypotension and cannot help to reduce the level of monitoring. |
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Authors:
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François-Xavier Duchateau; Adeline Max; Sébastien Harscoat; Sonja Curac; Agnès Ricard-Hibon; Jean Mantz |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of emergency medicine : official journal of the European Society for Emergency Medicine Volume: 17 ISSN: 1473-5695 ISO Abbreviation: Eur J Emerg Med Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-26 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9442482 Medline TA: Eur J Emerg Med Country: England |
Other Details:
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Languages: eng Pagination: 142-5 Citation Subset: IM |
Affiliation:
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Department of Anaesthesiology and Intensive Care, Beaujon University Hospital, Clichy, France. fxduchateau@orange.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antihypertensive Agents / therapeutic use Case-Control Studies Female France / epidemiology Humans Hypotension, Controlled / methods* Infant, Newborn Infant, Premature* Nicardipine / therapeutic use* Oxytocin / antagonists & inhibitors Patient Transfer* Pregnancy Risk Risk Factors Tocolytic Agents / therapeutic use* Vasotocin / analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Tocolytic Agents; 50-56-6/Oxytocin; 55985-32-5/Nicardipine; 9034-50-8/Vasotocin; 90779-69-4/atosiban |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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