Document Detail


Comparison of the baroreceptor-heart rate reflex effects of moxonidine, rilmenidine and clonidine in conscious rabbits.
MedLine Citation:
PMID:  9851569     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 10 conscious rabbits, the baroreceptor-heart rate (HR) reflex effects of centrally acting antihypertensive agents with high affinity for imidazoline receptors (IRs), moxonidine and rilmenidine, were compared with clonidine which acts predominantly via central alpha2-adrenoceptors. Dose regimens were chosen to give similar hypotension (-17+/-1 mm Hg) and bradycardia (-27+/-2 b/min) for all three agents given into the fourth ventricle. Baroreceptor-HR reflex curves were assessed by i.v. drug induced changes in blood pressure. With all treatments, the baroreflex curves with both vagal and sympathetic effectors intact were shifted to the left, corresponding to the hypotension, and the bradycardia plateau was reduced. Rilmenidine and moxonidine also reduced the upper plateau such that the curves were shifted parallel down the HR scale with no change in the HR range. By contrast, clonidine only decreased the lower plateau, and thus increased HR range (+19+/-6%). Moxonidine, but not rilmenidine, reduced the baroreflex gain by reducing the curvature. Clonidine also decreased curvature but this did not result in a reduction in gain as it was offset by the increase in HR range. The gain and range of the cardiac sympathetic component, as assessed after vagal blockade, was reduced by rilmenidine by 53 and 40% respectively, but was not affected by the other agents. The calculated vagal component of the curves showed that all agents produced a greater vagal bradycardia in response to a rise in pressure and that both rilmenidine and clonidine increased vagal HR range. The present study results show that many of the baroreflex effects of clonidine, such as facilitating cardiac vagal responses, are shared by the second generation agent rilmenidine, suggesting that they are primarily due to alpha2-adrenoceptor activation. In addition, the inhibition of the sympathetic component of the baroreflex, observed with rilmenidine, and not clonidine suggests that this effect may involve IRs. By contrast moxonidine, the most specific agent for I1 receptors, produces mainly a baroreflex independent inhibition of cardiac sympathetic activity with little effect on vagal activity.
Authors:
S J Godwin; C F Tortelli; M L Parkin; G A Head
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  72     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1999-03-18     Completed Date:  1999-03-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  195-204     Citation Subset:  IM    
Affiliation:
Neuropharmacology Laboratory, Baker Medical Research Institute, Melbourne, Victoria, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / administration & dosage,  pharmacology*
Algorithms
Animals
Antihypertensive Agents / administration & dosage,  pharmacology*
Baroreflex / drug effects*
Blood Pressure / drug effects
Clonidine / administration & dosage,  pharmacology*
Female
Heart Rate / drug effects*
Imidazoles / administration & dosage,  pharmacology*
Injections, Intraventricular
Male
Oxazoles / administration & dosage,  pharmacology*
Rabbits
Sympathetic Nervous System / drug effects,  physiology
Vagus Nerve / drug effects,  physiology
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Antihypertensive Agents; 0/Imidazoles; 0/Oxazoles; 4205-90-7/Clonidine; 54187-04-1/rilmenidine; 75438-57-2/moxonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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