Document Detail

Comparison of bare-metal stenting with minimally invasive bypass surgery for stenosis of the left anterior descending coronary artery: 10-year follow-up of a randomized trial.
MedLine Citation:
PMID:  23347858     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this prospective, randomized trial was to assess the 10-year long-term safety and effectiveness of percutaneous coronary intervention (PCI) and minimally invasive direct coronary artery bypass surgery (MIDCAB) for the treatment of proximal left anterior descending (LAD) lesions.
BACKGROUND: Long-term follow-up data comparing PCI and MIDCAB surgery for isolated proximal LAD lesions are sparse.
METHODS: Patients with significant isolated proximal LAD stenoses were randomized either to PCI with bare-metal stents (n = 110) or MIDCAB (n = 110). At 10 years, data were obtained with respect to the primary endpoint (death, myocardial infarction, target vessel revascularization). Angina was assessed by the Canadian Cardiovascular Society classification.
RESULTS: Follow-up was conducted for 212 patients at a median time of 10.3 years. There were no significant differences in the binary primary composite endpoint (47% vs. 36%; p = 0.12) and hard endpoints (death and infarction) between PCI and MIDCAB. However, a higher target vessel revascularization rate in the PCI group (34% vs. 11%; p < 0.01) was observed. Clinical symptoms improved significantly from baseline and were similar between both treatment groups.
CONCLUSIONS: At 10-year follow-up, PCI and MIDCAB in isolated proximal LAD lesions yielded similar long-term outcomes regarding the primary composite clinical endpoint. Target vessel revascularization was more frequent in the PCI group.
Stephan Blazek; David Holzhey; Camelia Jungert; Michael A Borger; Georg Fuernau; Steffen Desch; Ingo Eitel; Suzanne de Waha; Philipp Lurz; Gerhard Schuler; Friedrich-Wilhelm Mohr; Holger Thiele
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JACC. Cardiovascular interventions     Volume:  6     ISSN:  1876-7605     ISO Abbreviation:  JACC Cardiovasc Interv     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-07-09     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  101467004     Medline TA:  JACC Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  20-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Angina Pectoris / etiology
Coronary Artery Bypass* / adverse effects,  mortality
Coronary Stenosis / mortality,  surgery,  therapy*
Disease-Free Survival
Kaplan-Meier Estimate
Myocardial Infarction / etiology
Percutaneous Coronary Intervention / adverse effects,  instrumentation*,  mortality
Prospective Studies
Prosthesis Design
Surgical Procedures, Minimally Invasive
Time Factors
Treatment Outcome
Reg. No./Substance:
Comment In:
JACC Cardiovasc Interv. 2013 Jan;6(1):27-8   [PMID:  23347859 ]

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