Document Detail


Comparison of axial lengths in occludable angle and angle-closure glaucoma--the Bhaktapur Glaucoma Study.
MedLine Citation:
PMID:  21150676     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
PURPOSE: To compare the anterior chamber depth (ACD) and axial length of eyes in a population-based sample among normal, occludable angle, and primary angle-closure glaucoma (PACG) groups.
METHODS: Totally, 3979 subjects from a population-based glaucoma prevalence study underwent complete ocular examination including four mirror gonioscopy. An angle in which >270 degrees of the posterior trabecular meshwork could not be seen was considered occludable. PACG was considered when there were features of primary angle closure (eye with an occludable angle, peripheral anterior synechiae, increased intraocular pressure, iris whorling, lens opacities, or excessive pigment deposition on the trabecular surface) and optic disc with glaucomatous damage. A handheld ultrasonic biometer was used to measure the ACD and the axial length of subjects. The ACD and axial length were measured on all subjects with occludable angles (n = 86), PACG (n = 17) and a random subgroup of normal subjects (n = 685). The measurements were compared among the groups and statistically analyzed using independent t-test, one-way analysis of variance, χ2 test, and logistic regression.
RESULTS: The mean age among occludable angle and angle-closure glaucoma groups was 59.64 ± 9.70 and 71.23 ± 8.5 years, respectively, which was significantly higher (p < 0.001) than the mean of 54.03 ± 10.90 years among normal subjects. In the occludable angle group, the ACD (2.55 ± 0.69) was significantly different (p < 0.001) than the normal group (2.85 ± 0.39). The axial length (22.08 ± 0.83) in the occludable angle group was also considerably different (p < 0.001) when compared with the normal group (22.62 ± 0.90). In PACG group, the ACD and axial length were 2.48 ± 0.22 and 22.02 ± 0.59, respectively. The risk of having an occludable angle decreased with per unit millimeter increase in ACD (odds ratio, 0.24; 95% confidence intervals, 0.12-0.50) and axial length (odds ratio, 0.49; 95% confidence intervals, 0.36-0.67) after adjusting the effect of age and sex.
CONCLUSIONS: The eyes in Nepalese population with occludable angle and angle-closure glaucoma appear to have significantly shallower anterior chambers and shorter axial lengths when compared with the normal group.
Authors:
Suman S Thapa; Indira Paudyal; Shankar Khanal; Nabin Paudel; Ger H M B van Rens
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Optometry and vision science : official publication of the American Academy of Optometry     Volume:  88     ISSN:  1538-9235     ISO Abbreviation:  Optom Vis Sci     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904931     Medline TA:  Optom Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-4     Citation Subset:  IM    
Affiliation:
Nepal Glaucoma Eye Clinic, Tilganga Institute of Ophthalmology, Kathmandu, Nepal. ssthapa@tilganga.com.np
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