Document Detail


Comparison of automatic quantification software for the measurement of ventricular volume and ejection fraction in gated myocardial perfusion SPECT.
MedLine Citation:
PMID:  12612466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to compare the performance of three different software packages for the calculation of ejection fraction (EF) and end diastolic volume (EDV) from gated myocardial single photon emission computed tomography studies. Two hundred patients undergoing gated stress myocardial perfusion scans were analysed retrospectively. Patients were grouped as follows: small heart (n=31), normal perfusion scan (n=71), and scan with perfusion defects (n=98). EF and EDV were calculated for each using QGS (Cedars Sinai, Los Angeles, CA), 4D-MSPECT (University of Michigan, Ann Arbor, MI), and ECT (Emory University, Atlanta, GA). Bland-Altman plots, repeated measures ANOVA, and linear regression analysis were used to compare methods. Correlation coefficients between the methods for both EF and EDV were high, greater than 0.9. However, Bland-Altman plots revealed a large standard deviation of the difference between methods, preventing the confident estimate of the value of one method from an observation of another. Despite good correlation, the variance between methods was high. These algorithms behave differently, produce widely variable results from one another, and should not be used interchangeably. It may prove prudent for laboratories to independently validate the software algorithm that is chosen against a 'gold standard' using their own population.
Authors:
D P Lum; M N Coel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  24     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-03     Completed Date:  2003-10-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  259-66     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, The Queen's Medical Center, and The John A Burns School of Medicine, University of Hawaii, Honolulu, Hawii 96813, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Automation / methods
Chest Pain / radionuclide imaging
Coronary Disease / radionuclide imaging
Electrocardiography
Exercise Test
Female
Heart Diseases / classification,  radionuclide imaging*
Heart Failure / radionuclide imaging
Humans
Male
Middle Aged
Retrospective Studies
Software
Stroke Volume / physiology*
Tomography, Emission-Computed, Single-Photon / methods*
Ventriculography, First-Pass / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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