Document Detail


Comparison of atracurium and succinylcholine for electroconvulsive therapy in a patient with atypical plasma cholinesterase.
MedLine Citation:
PMID:  3581397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Succinylcholine 2-5 mg or atracurium 10-15 mg were given on five separate occasions to a 24-year-old, 64 kg woman homozygous for atypical plasma cholinesterase who was undergoing electroconvulsive therapy (ECT). Atracurium blockade was reversed with atropine, 0.6 mg and edrophonium, 35 mg. Train-of-four stimulation was applied to the ulnar nerve and the force of contraction of the adductor pollicis muscle was recorded. Doses producing 90 per cent first twitch blockade were 2.5 and 15 mg for succinylcholine and atracurium respectively. The onset of action was 6 min for both relaxants, and time to 90 per cent first twitch recovery was 20 min for succinylcholine and 16 min for the atracurium-edrophonium combination. It is concluded that the use of atracurium in these patients does not offer marked advantages over small doses of succinylcholine.
Authors:
D R Hickey; J P O'Connor; F Donati
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Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  34     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-07-14     Completed Date:  1987-07-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  280-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Atracurium / administration & dosage*
Cholinesterases / blood*,  genetics
Electroconvulsive Therapy*
Female
Homozygote
Humans
Schizophrenia, Catatonic / therapy
Succinylcholine / administration & dosage*
Chemical
Reg. No./Substance:
306-40-1/Succinylcholine; 64228-79-1/Atracurium; EC 3.1.1.8/Cholinesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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