Document Detail

Comparison of atracurium-induced neuromuscular blockade in neonates, infants and children.
MedLine Citation:
PMID:  3345278     Owner:  NLM     Status:  MEDLINE    
The potency of atracurium was determined in neonates, infants and children during thiopentone-fentanyl-nitrous oxide in oxygen anaesthesia using single dose-response curves. The effective doses producing 50% depression of the first twitch of the train-of-four were significantly lower in neonates and infants than in children (82 and 112 v. 135 micrograms kg-1). Following a standard dose of atracurium 0.5 mg kg-1, 95% depression of the first twitch occurred more rapidly in neonates than in children (0.9 v. 1.4 min), while recovery to 10% of the control twitch height occurred more rapidly in neonates than in the other two groups (22.7 v. 29.7 and 28.6 min). It is concluded that neonates and infants require less atracurium to produce a given degree of neuromuscular blockade compared with older children. However, prompt recovery can be expected in all healthy paediatric patients following a standard intubating dose of atracurium 0.5 mg kg-1.
G Meakin; E A Shaw; R D Baker; P Morris
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  60     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-04-14     Completed Date:  1988-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Department of Anaesthesia, Royal Manchester Children's Hospital, Pendlebury.
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MeSH Terms
Anesthesia, General
Atracurium* / pharmacology
Child, Preschool
Dose-Response Relationship, Drug
Infant, Newborn
Muscle Contraction / drug effects
Nerve Block*
Time Factors
Reg. No./Substance:

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