Document Detail

Comparison of arterial wall mechanics in normotensive and spontaneously hypertensive rats.
MedLine Citation:
PMID:  464107     Owner:  NLM     Status:  MEDLINE    
Segments of carotid artery from Wistar (NW), Kyoto Wistar (WKY), and spontaneously hypertensive rats (SHR) were used to compare mechanical properties and connective tissue composition. Pressure-diameter measurements were made under conditions of active (5 microgram/ml norepinephrine) and passive (0 mM Ca2+ and 2 mM EGTA) smooth muscle. Systolic blood pressures averaged NW, 121 +/- 3; WKY, 124 +/- 4; and SHR, 187 +/- 5 MMHg. Passive mechanics were stiffest in SHR and most compliant in NW arteries. No differences in collagen-elastin ratio were found but collagen + elastin was lowest in SHR and highest in NW carotids. These results are not consistent with current concepts of the contribution of connective tissue elements to passive mechanics. Maximum stress development was NW, 561 +/- 49; WKY, 735 +/- 50; and SHR, 944 +/- 79 X 10(3) dyn/cm2. Diameter reductions to NE at 100 mmHg were NW, 17.6 +/- 2.4%; WKY, 16.7 +/- 2.0%; and SHR, 24.8 +/- 2.4%. The former suggests different contractile protein contents or more efficient intercellular force coupling in SHR. The latter suggests a more effective contractile apparatus as a result of stiffer passive muscle elements and/or a relatively larger wall thickness.
R H Cox
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  237     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-09-25     Completed Date:  1979-09-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H159-67     Citation Subset:  IM    
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MeSH Terms
Blood Pressure
Carotid Arteries / analysis,  physiopathology*
Collagen / analysis
Elastin / analysis
Hypertension / physiopathology*
Muscle, Smooth / physiopathology*
Norepinephrine / pharmacology
Vascular Resistance*
Reg. No./Substance:
51-41-2/Norepinephrine; 9007-34-5/Collagen; 9007-58-3/Elastin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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