Document Detail


Comparison of arterial transit times estimated using arterial spin labeling.
MedLine Citation:
PMID:  21863374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compare arterial transit time estimates from two efficient transit time mapping techniques using arterial spin labeling (ASL)-flow encoded arterial spin tagging (FEAST) and Look-Locker ASL (LL-ASL). The effects of bipolar gradients and label location were investigated.
MATERIALS AND METHODS: Six healthy subjects were scanned with pseudo-continuous ASL (pCASL) FEAST and pulsed (PASL) and pCASL variants of LL-ASL at different labeling locations with and without bipolar gradients. Application of transit time mapping was demonstrated in a clinical case.
RESULTS: Mean (±SD) macrovascular transit times were 363 ± 39, 676 ± 73 and 908 ± 170 ms for LL-PASL, LL-pCASL with labeling offsets of 60 and 90 mm respectively, showing linear dependence on labeling locations. Mean microvascular transit time for LL-pCASL was 1,463±135 ms, in good agreement with the FEAST estimate of 1,444 ± 128 ms. Data acquired from a patient with stroke demonstrate how transit time and CBF maps provide complementary information for clinical diagnosis.
CONCLUSION: Both FEAST and LL-ASL provide transit time information in clinically acceptable scan times. Bipolar gradients can be used to tailor transit time estimates for different experimental and clinical situations.
Authors:
Yufen Chen; Danny J J Wang; John A Detre
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2011-08-24
Journal Detail:
Title:  Magma (New York, N.Y.)     Volume:  25     ISSN:  1352-8661     ISO Abbreviation:  MAGMA     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-07-23     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  9310752     Medline TA:  MAGMA     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  135-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Algorithms
Blood Flow Velocity / physiology
Brain / blood supply*
Cerebral Arteries / physiology*
Cerebrovascular Circulation / physiology
Female
Humans
Magnetic Resonance Imaging / instrumentation*
Microcirculation / physiology
Regional Blood Flow / physiology
Signal-To-Noise Ratio
Spin Labels*
Grant Support
ID/Acronym/Agency:
MH080729/MH/NIMH NIH HHS; MH080892/MH/NIMH NIH HHS; MH080892-S1/MH/NIMH NIH HHS; NS045839/NS/NINDS NIH HHS; NS058386/NS/NINDS NIH HHS; R01 MH080892-04/MH/NIMH NIH HHS; RR002305/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Spin Labels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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