| Comparison of arterial transit times estimated using arterial spin labeling. | |
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MedLine Citation:
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PMID: 21863374 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: To compare arterial transit time estimates from two efficient transit time mapping techniques using arterial spin labeling (ASL)-flow encoded arterial spin tagging (FEAST) and Look-Locker ASL (LL-ASL). The effects of bipolar gradients and label location were investigated. MATERIALS AND METHODS: Six healthy subjects were scanned with pseudo-continuous ASL (pCASL) FEAST and pulsed (PASL) and pCASL variants of LL-ASL at different labeling locations with and without bipolar gradients. Application of transit time mapping was demonstrated in a clinical case. RESULTS: Mean (±SD) macrovascular transit times were 363 ± 39, 676 ± 73 and 908 ± 170 ms for LL-PASL, LL-pCASL with labeling offsets of 60 and 90 mm respectively, showing linear dependence on labeling locations. Mean microvascular transit time for LL-pCASL was 1,463±135 ms, in good agreement with the FEAST estimate of 1,444 ± 128 ms. Data acquired from a patient with stroke demonstrate how transit time and CBF maps provide complementary information for clinical diagnosis. CONCLUSION: Both FEAST and LL-ASL provide transit time information in clinically acceptable scan times. Bipolar gradients can be used to tailor transit time estimates for different experimental and clinical situations. |
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Authors:
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Yufen Chen; Danny J J Wang; John A Detre |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-24 |
Journal Detail:
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Title: Magma (New York, N.Y.) Volume: - ISSN: 0968-5243 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9310752 Medline TA: MAGMA Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Center for Advanced MRI, Department of Radiology, Northwestern University, 737 N Michigan Ave. 16th Flr., Chicago, IL, 60611, USA, yfchen@northwestern.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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