Document Detail

Comparison of antiviral efficiency of immune responses in shrimp.
MedLine Citation:
PMID:  18721886     Owner:  NLM     Status:  MEDLINE    
The antiviral effectiveness of three major immune responses including phagocytosis, apoptosis and proPO system in the shrimp Marsupenaeus japonicus was characterized. It was found that the suppression of apoptosis and phagocytosis in vivo by their corresponding inhibitors resulted in the increase of white spot syndrome virus (WSSV) copies and shrimp mortality, whereas the inhibition of phenol oxidase generated the least influence on WSSV infection and shrimp mortality. These results suggest that apoptosis and phagocytosis were the essential immune responses to protect shrimp from virus infection, while the phenol-oxidase-dependent proPO system plays a comparatively minor role in antiviral defense of shrimp.
Wei Wang; Xiaobo Zhang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-05
Journal Detail:
Title:  Fish & shellfish immunology     Volume:  25     ISSN:  1050-4648     ISO Abbreviation:  Fish Shellfish Immunol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-05     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505220     Medline TA:  Fish Shellfish Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  522-7     Citation Subset:  IM    
Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, State Oceanic Administration, Xiamen 361005, People's Republic of China.
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MeSH Terms
DNA Virus Infections / immunology*
Immune System / physiology*
Immunosuppressive Agents / pharmacology
Monophenol Monooxygenase / antagonists & inhibitors
Penaeidae / drug effects,  immunology*,  virology*
White spot syndrome virus 1*
Reg. No./Substance:
0/Immunosuppressive Agents; EC Monooxygenase

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