Document Detail

Comparison of the antisecretory effects of omeprazole when administered intravenously, as acid-stable granules and as an oral paste in horses.
MedLine Citation:
PMID:  10696295     Owner:  NLM     Status:  MEDLINE    
The antisecretory activity of omeprazole on gastric acid when administered i.v., intragastrically or per os, was evaluated in 2 female and 3 castrated male horses. Each horse had been prepared with a chronic indwelling gastric cannula. A single i.v. administration of omeprazole (1.5 mg/kg bwt) was effective in abolishing basal and pentagastrin (PG)-stimulated acid secretion. Once daily, nasogastric administration of omeprazole in acid-stable granules for 5 days inhibited acid secretion in a dose-dependent manner: 57% (1.5 mg/kg bwt) and 98% (5.0 mg/kg bwt) reduction of PG-stimulated acid secretion. The degree of inhibition was maintained over a 19 day treatment period with once daily dosing. A prototype oral paste formulation containing either acid-stable omeprazole granules or uncoated omeprazole powder was equipotent when compared to a similar dosage of acid-stable omeprazole granules administered by nasogastric tube. A dose-dependent inhibition was seen with the oral paste formulation containing omeprazole powder: 55% (1.5 mg/kg bwt) and 77% (3.0 mg/kg bwt) reduction of PG-stimulated acid secretion after 5 days. Therefore, a paste formulation of omeprazole powder may offer an effective, easily administered, once daily acid inhibitory treatment for gastric ulcer disease in horses.
M L Haven; K Dave; J A Burrow; A M Merritt; D Harris; D Zhang; G J Hickey
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Equine veterinary journal. Supplement     Volume:  -     ISSN:  -     ISO Abbreviation:  Equine Vet J Suppl     Publication Date:  1999 Apr 
Date Detail:
Created Date:  2000-03-24     Completed Date:  2000-03-24     Revised Date:  2007-05-18    
Medline Journal Info:
Nlm Unique ID:  9614088     Medline TA:  Equine Vet J Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  54-8     Citation Subset:  IM    
Department of Animal Health, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
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MeSH Terms
Administration, Oral
Anti-Ulcer Agents / administration & dosage*,  pharmacology
Dose-Response Relationship, Drug
Enzyme Inhibitors / administration & dosage*,  pharmacology
Gastric Juice / drug effects*
Horses / metabolism*
Hydrogen-Ion Concentration
Injections, Intravenous / veterinary
Intubation, Gastrointestinal / veterinary
Omeprazole / administration & dosage*,  pharmacology
Reg. No./Substance:
0/Anti-Ulcer Agents; 0/Enzyme Inhibitors; 0/Ointments; 0/Suspensions; 73590-58-6/Omeprazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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