Document Detail

Comparison of antioxidant enzyme activity in the internal spermatic vein and brachial veins of patients with infertile varicocele.
MedLine Citation:
PMID:  18264794     Owner:  NLM     Status:  MEDLINE    
AIM: Recent studies have shown that both oxidative and reductive stresses are present within the internal spermatic vein of patients with varicocele. The aim of this study was to compare the activities of antioxidant enzymes in the internal spermatic vein and brachial vein of patients with varicocele. METHODS: Fifteen primary infertile varicocele patients and ten normal-nonvaricocele-fertile control subjects participated in this study. The patients and subjects were first given a physical and color doppler examination, and then whole blood samples were drawn from the brachial vein and a dilated internal spermatic vein during surgery. Superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) enzyme activities were assessed by enzymatic methods, and the results were compared using the Mann-Whitney U test. RESULTS: The activity of SOD in the internal spermatic veins and brachial veins of patients with varicocele was 60.17+/-2.15 and 42.10+/-1.60 U/g protein, respectively; that of GSH-Px was 5.44+/-0.14 and 3.92+/-0.14 U/g protein, respectively. The results were statistically significant (P<0.05). In the control group, the activity of SOD in the internal spermatic veins and brachial veins was 43.12+/-1.80 and 40.01+/-2.10 U/g protein, respectively; that of GSH-Px was 3.35+/-0.20 and 3.7+/-0.10 U/g protein, respectively (P>0.05). CONCLUSIONS: Increased antioxidant enzyme activity in the internal spermatic vein may be due to increased oxidative stress in the internal spermatic vein: the increase in antioxidant enzyme activity may be a response to offset the toxic actions of reactive oxygen species. Further studies are needed to confirm this suggestion.
Emin Ozbek; Mustafa Cekmen; Abdulmuttalip Simsek; Yusuf Turkoz; Ahmet Soylu; Y Ozlem Ilbey; M Derya Balbay
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-02-09
Journal Detail:
Title:  International urology and nephrology     Volume:  40     ISSN:  0301-1623     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2008  
Date Detail:
Created Date:  2008-07-29     Completed Date:  2009-01-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Hungary    
Other Details:
Languages:  eng     Pagination:  679-83     Citation Subset:  IM    
Department of Urology, Bezm-I Alem Valide Sultan Vakif Gureba Research and Education Hospital, Istanbul, Turkey.
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MeSH Terms
Arm / blood supply*
Glutathione Peroxidase / metabolism*
Infertility, Male / enzymology*,  ultrasonography
Oxidative Stress
Spermatic Cord / blood supply*,  enzymology
Statistics, Nonparametric
Superoxide Dismutase / metabolism*
Ultrasonography, Doppler
Varicocele / enzymology*,  ultrasonography
Reg. No./Substance:
EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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